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  • Translational Models of Parkinson's Disease and related Movement Disorders

    Translational Models of Parkinson's Disease and related Movement Disorders by Mohamed, Wael;

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    A termék adatai:

    • Kiadó Elsevier Science
    • Megjelenés dátuma 2024. november 28.

    • ISBN 9780443161285
    • Kötéstípus Puhakötés
    • Terjedelem386 oldal
    • Méret 279x215 mm
    • Súly 1070 g
    • Nyelv angol
    • 616

    Kategóriák

    Hosszú leírás:

    Translational Models of Parkinson's Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson's Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson's Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.

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    Tartalomjegyzék:

    Section I. Understanding PD and related movement disorders
    1. Neuroinflammation, glymphatic system, and Parkinson's disease
    2. Pharmacotherapy of PD and related movements disorders and their limitations
    3. Diagnosis and biomarkers of Parkinson's disease and related movement disorders
    4. OMICS and bioinformatics in Parkinson disease and related movements disorders
    5. Modeling Parkinson's disease with the alpha-synuclein protein
    6. ?-Synuclein seeding assay and analysis
    Section II. Mammalian models of Parkinson's disease
    7. SHH, nurr1, pitx3, and en1 models for Parkinson's disease
    8. Stem cell for PD: Technical considerations
    9. Deep brain stimulation using animal models of Parkinson's disease
    10. The MitoPark mouse model of Parkinson's disease
    11. The beta-sitosterol beta-D-glucoside (BSSG) rat model of Parkinson's disease
    Section III. Invertebrate models of Parkinson's disease
    12. SCA1 zebrafish model
    13. Various zebrafish models of Parkinson's disease: What gives us hope
    14. Drosophila PD model
    15. Caenorhabditis elegans models of tauopathy
    16. LRRK2 in Caenorhabditis elegans model
    Section IV. Ethics and regulations related to translational PD models
    17. Confounding factors for validation of PD models
    18. Neurobehavioral characterization of PD models
    19. Ethical regulations for induction and validation of PD models
    20. The OMICS and PD models: Hopes or hypes
    21. Parkinson's disease from an Ayurveda perspective: Opportunities and challenges for further research

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