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  • The Molecular and Supramolecular Chemistry of Carbohydrates: Chemical Introduction to the Glycosciences

    The Molecular and Supramolecular Chemistry of Carbohydrates by David, Serge;

    Chemical Introduction to the Glycosciences

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    A termék adatai:

    • Kiadó OUP Oxford
    • Megjelenés dátuma 1997. október 16.

    • ISBN 9780198500469
    • Kötéstípus Puhakötés
    • Terjedelem330 oldal
    • Méret 233x156x18 mm
    • Súly 502 g
    • Nyelv angol
    • Illusztrációk numerous line figures, tables
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    Kategóriák

    Rövid leírás:

    Contemporary science has coined new terms such as glycoscience or glycobiology. Research on carbohydrates simultaneously requires specialist knowledge in many diverse areas - from the theory of molecular orbitals to immunochemistry with its close links to medicine, via synthetic chemistry, crystallography, enzymology and other areas. Every advance made in one of these areas affects most of the others, and the researcher needs a good understanding of their
    significance. For the first time a unified treatment of the glycosciences is proposed within the framework of organic chemistry, by means of detailed examples. The authors provide a large amount of concrete data (tables, drawings, and epxerimental methods) so that the reader can better visualize the
    facts.

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    Hosszú leírás:

    There is currently a great deal of interest in carbohydrate research among chemists and biologists, in both academic and industrial laboratories. One reason is the involvement of oligosaccharide molecules in many recognition phenomena in the living world. Another reason is the growing demand for chiral synthesissugars are an amazingly cheap source of chirality but must be efficiently processed. Thirdly the role of conformation in carbohydrate interactions has
    stimulated much experimental and theoretical work. There are causal links between advances in each of these fields, from molecular orbitals to immunochemistry, so that no research worker in his narrow specialisation can afford to ignore what is going on elsewhere. Thus a body of knowledge has been built
    from what is now called the 'glycosciences'. This book attempts to describe glycosciences in their true perspective. Organic chemistry is the backbone of the presentation, but carbohydrate chemistry offers a wealth of supramolecular associations. This book is unique, among similar texts on carbohydrates, in that half its content is devoted to the description of important examples of such interactions. The opening chapters deal with the problems of configuration, conformation, derivatization,
    and modifications of monosaccharides, with examples on their utilization in total synthesis. The anomeric effectthe most popular of all stereoelectronic effects, and a gift to carbohydrate chemists and chemists in generalis discussed at length. The following chapters deal with oligosaccharides; the
    essentials of enzymic synthesis, with its high performances; and the sialic acids, which are at the forefront of carbohydrate research. The author describes recognition reactions, including blood group phenomena, interactions involving sialic acids, the active site of heparin, tumour markers, and selectins. The association of sugars with small molecules, notably with inorganic species, is the subject of another chapter. Throughout the book, great attention has been given to practical details
    especially in the description of experiments involving unfamiliar techniques. Many tables, figures, diagrams, experimental protocols and a survey of the literature up to March 1996 will help the reader to understand the salient facts and visualize a broad spectrum of ideas.

    This translation from the French will be of interest to both academic and industrial organic chemists working with oligosaccharides ... contains a great deal of useful data.

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    Tartalomjegyzék:

    Configuration of monosaccharides
    Conformation of monosaccharides and their derivatives
    Alkyl and aryl glycosides and glycosamines
    Nomenclature
    Reactions of hydroxyl groups
    Reactions of carbonyl groups and hemiacetals
    Changes of configuration, unsaturated and branched-chain sugars
    Sugars in chiral synthesis
    Oligosaccharides : configuration and analysis
    Chemical transformations and synthesis of oligosaccharides
    Associations with anions, cations, and inorganic molecules
    Sialic and sialylated oligosaccharides
    Glycoconjugates
    Structure of some crystallized sugar-protein complexes
    Antigens and antibodies. Lectins
    ABH and related blood group antigens
    Important recognition events involving oligosaccharides in the living world
    Oligosaccharides as ligands to DNA

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