The Molecular and Supramolecular Chemistry of Carbohydrates
Chemical Introduction to the Glycosciences
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Product details:
- Publisher OUP Oxford
- Date of Publication 16 October 1997
- ISBN 9780198500469
- Binding Paperback
- No. of pages330 pages
- Size 233x156x18 mm
- Weight 502 g
- Language English
- Illustrations numerous line figures, tables 0
Categories
Short description:
Contemporary science has coined new terms such as glycoscience or glycobiology. Research on carbohydrates simultaneously requires specialist knowledge in many diverse areas - from the theory of molecular orbitals to immunochemistry with its close links to medicine, via synthetic chemistry, crystallography, enzymology and other areas. Every advance made in one of these areas affects most of the others, and the researcher needs a good understanding of their
significance. For the first time a unified treatment of the glycosciences is proposed within the framework of organic chemistry, by means of detailed examples. The authors provide a large amount of concrete data (tables, drawings, and epxerimental methods) so that the reader can better visualize the
facts.
Long description:
There is currently a great deal of interest in carbohydrate research among chemists and biologists, in both academic and industrial laboratories. One reason is the involvement of oligosaccharide molecules in many recognition phenomena in the living world. Another reason is the growing demand for chiral synthesissugars are an amazingly cheap source of chirality but must be efficiently processed. Thirdly the role of conformation in carbohydrate interactions has
stimulated much experimental and theoretical work. There are causal links between advances in each of these fields, from molecular orbitals to immunochemistry, so that no research worker in his narrow specialisation can afford to ignore what is going on elsewhere. Thus a body of knowledge has been built
from what is now called the 'glycosciences'. This book attempts to describe glycosciences in their true perspective. Organic chemistry is the backbone of the presentation, but carbohydrate chemistry offers a wealth of supramolecular associations. This book is unique, among similar texts on carbohydrates, in that half its content is devoted to the description of important examples of such interactions. The opening chapters deal with the problems of configuration, conformation, derivatization,
and modifications of monosaccharides, with examples on their utilization in total synthesis. The anomeric effectthe most popular of all stereoelectronic effects, and a gift to carbohydrate chemists and chemists in generalis discussed at length. The following chapters deal with oligosaccharides; the
essentials of enzymic synthesis, with its high performances; and the sialic acids, which are at the forefront of carbohydrate research. The author describes recognition reactions, including blood group phenomena, interactions involving sialic acids, the active site of heparin, tumour markers, and selectins. The association of sugars with small molecules, notably with inorganic species, is the subject of another chapter. Throughout the book, great attention has been given to practical details
especially in the description of experiments involving unfamiliar techniques. Many tables, figures, diagrams, experimental protocols and a survey of the literature up to March 1996 will help the reader to understand the salient facts and visualize a broad spectrum of ideas.
This translation from the French will be of interest to both academic and industrial organic chemists working with oligosaccharides ... contains a great deal of useful data.
Table of Contents:
Configuration of monosaccharides
Conformation of monosaccharides and their derivatives
Alkyl and aryl glycosides and glycosamines
Nomenclature
Reactions of hydroxyl groups
Reactions of carbonyl groups and hemiacetals
Changes of configuration, unsaturated and branched-chain sugars
Sugars in chiral synthesis
Oligosaccharides : configuration and analysis
Chemical transformations and synthesis of oligosaccharides
Associations with anions, cations, and inorganic molecules
Sialic and sialylated oligosaccharides
Glycoconjugates
Structure of some crystallized sugar-protein complexes
Antigens and antibodies. Lectins
ABH and related blood group antigens
Important recognition events involving oligosaccharides in the living world
Oligosaccharides as ligands to DNA
