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  • The calcitonin gene-related peptide family: form, function and future perspectives

    The calcitonin gene-related peptide family by Hay, Deborah L.; Dickerson, Ian M.;

    form, function and future perspectives

      • 20% KEDVEZMÉNY?

      • A kedvezmény csak az 'Értesítés a kedvenc témákról' hírlevelünk címzettjeinek rendeléseire érvényes.
      • Kiadói listaár EUR 160.49
      • Az ár azért becsült, mert a rendelés pillanatában nem lehet pontosan tudni, hogy a beérkezéskor milyen lesz a forint árfolyama az adott termék eredeti devizájához képest. Ha a forint romlana, kissé többet, ha javulna, kissé kevesebbet kell majd fizetnie.

        66 563 Ft (63 393 Ft + 5% áfa)
      • Kedvezmény(ek) 20% (cc. 13 313 Ft off)
      • Kedvezményes ár 53 250 Ft (50 714 Ft + 5% áfa)

    66 563 Ft

    db

    Beszerezhetőség

    Megrendelésre a kiadó utánnyomja a könyvet. Rendelhető, de a szokásosnál kicsit lassabban érkezik meg.

    Why don't you give exact delivery time?

    A beszerzés időigényét az eddigi tapasztalatokra alapozva adjuk meg. Azért becsült, mert a terméket külföldről hozzuk be, így a kiadó kiszolgálásának pillanatnyi gyorsaságától is függ. A megadottnál gyorsabb és lassabb szállítás is elképzelhető, de mindent megteszünk, hogy Ön a lehető leghamarabb jusson hozzá a termékhez.

    Hosszú leírás:

    In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

    Több

    Tartalomjegyzék:

    Molecular and Functional Evolution of the Adrenomedullin Family in Vertebrates: What Do Fish Studies Tell Us?.- Ligand Binding and Activation of the CGRP Receptor.- Understanding Amylin Receptors.- The CGRP-Receptor Component Protein: A Regulator for CLR Signaling.- The Calcitonin Peptide Family: What Can We Learn from Receptor Knock Out and Transgenic Mice.- Gene Targeted Mouse Models of Adrenomedullin Signaling.- Genetic Regulation of CGRP and Its Actions.- Vascular Actions of CGRP and Adrenomedullin: Mechanisms and Potential Contribution to Inflammation in the Cutaneous Microvasculature.- Insights into the Function of Intermedin/Adrenomedullin 2.- CGRP and Adrenomedullin as Pain-Related Peptides.- Amylinergic Control of Ingestive Behaviour.- CGRP Receptor Antagonists for Migraine: Challenges and Promises.- Calcitonin Receptor Expression in Embryonic, Foetal and Adult Tissues: Developmental and Pathophysiological Implications.- Conclusions and Future Perspectives.

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