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  • Pharmaceutical Biotechnology: A Focus on Industrial Application

    Pharmaceutical Biotechnology by Pessoa, Adalberto; Vitolo, Michele; Long, Paul Frederick;

    A Focus on Industrial Application

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    A termék adatai:

    • Kiadás sorszáma 1
    • Kiadó CRC Press
    • Megjelenés dátuma 2021. július 16.

    • ISBN 9781032006062
    • Kötéstípus Puhakötés
    • Terjedelem400 oldal
    • Méret 297x210 mm
    • Súly 1080 g
    • Nyelv angol
    • Illusztrációk 49 Illustrations, black & white; 120 Illustrations, color; 6 Halftones, black & white; 27 Halftones, color; 43 Line drawings, black & white; 93 Line drawings, color; 98 Tables, black & white
    • 179

    Kategóriák

    Rövid leírás:

    Pharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to Pharmaceutical Biotechnology, together with an industrial perspective. 

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    Hosszú leírás:

    Pharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to pharmaceutical biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with educators in mind, this book provides teachers with background material to enhance their classes and offers students and other readers an easy-to-read text that examines the step-by-step stages of the development of new biopharmaceuticals.


    Features:




    • Discusses specific points of great current relevance in relation to new processes as well as traditional processes



    • Addresses the main unitary operations used in the biopharmaceutical industry such as upstream and downstream



    • Includes chapters that allow a broad evaluation of the production process


    Dr. Adalberto Pessoa Jr. is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King’s College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products such as liquid–liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries.


    Dr. Michele Vitolo is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst) and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, chemical and food industries.


    Dr. Paul F. Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. He is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.

    Több

    Tartalomjegyzék:


    Chapter 1 Fundamentals of Biotechnology........................................................................................................................ 1


    Michele Vitolo


    Chapter 2 Thermodynamics Applied to Biomolecules.................................................................................................... 29


    Attilio Converti, Adalberto Pessoa Jr, Jônatas de Carvalho Silva, Rodrigo Lira de Oliveira, and


    Tatiana Souza Porto


    Chapter 3 Expression Systems for the Production of Therapeutic Recombinant Proteins...............................................43


    Amanda Mizukami, Adalberto Pessoa Jr, and Kamilla Swiech


    Chapter 4 Molecular Biology: Tools in Industrial Pharmaceutical Biotechnology..........................................................55


    Marina Gabriel Fontes and Gisele Monteiro


    Chapter 5 Molecular Biology Tools: Techniques and Enzymes.......................................................................................73


    Marina Gabriel Fontes and Gisele Monteiro


    Chapter 6 Bioinformatics Applied to the Development of Biomolecules of Pharmaceutical Interest.............................89


    Renata Bannitz Fernandes, Carlos Alexandre Breyer, Leonardo Schultz da Silva, Pedro Henrique


    Camargo Penna, Antônio Sérgio Kimus Braz, and Marcos Antonio de Oliveira


    Chapter 7 Bioprocesses: Microorganisms and Culture Media.......................................................................................115


    Ricardo Pinheiro de Souza Oliveira and Adalberto Pessoa Jr


    Chapter 8 Sterilization in Pharmaceutical Biotechnology..............................................................................................133


    Valéria C. Santos-Ebinuma, Fernanda de Oliveira, Nathalia V. Veríssimo, Jorge F. B. Pereira, and


    Adalberto Pessoa Jr


    Chapter 9 Kinetics of Cell Cultivation............................................................................................................................147


    Aldo Tonso, Adalberto Pessoa Jr, and Michele Vitolo


    Chapter 10 Bioreactors: Modes of Operation...................................................................................................................157


    Inês C. Roberto, Adalberto Pessoa Jr, and Aldo Tonso


    Chapter 11 Agitation and Aeration: Oxygen Transfer and Cell Respiration....................................................................181


    Aldo Tonso, Thiago Olitta Basso, Adalberto Pessoa Jr, and Ricardo Pinheiro de Souza Oliveira


    Chapter 12 Mammalian Cell Culture Technology...........................................................................................................195


    Patrícia Barros dos Santos, Patrícia Léo, Ricardo Pinheiro de Souza Oliveira, and


    Marco Antonio Stephano


    Chapter 13 Purification Process of Biomolecules............................................................................................................ 225


    Adalberto Pessoa Jr and Beatriz Vahan Kilikian


    Chapter 14 Lipopolysaccharides: Methods of Quantification and Removal from Biotechnological Products................239


    André M. Lopes, Jorge F. B. Pereira, João V. D. Molino, Felipe R. Lourenço, and Adalberto Pessoa-Jr


    Chapter 15 Enzymes: The Catalytic Proteins...................................................................................................................257


    Michele Vitolo


    Chapter 16 Enzymes as Drugs and Medicines................................................................................................................ 265


    Carlota de Oliveira Rangel-Yagui and Michele Vitolo


    Chapter 17 Aspects of the Immobilization Technique.....................................................................................................273


    Michele Vitolo


    Chapter 18 Biomolecules in Analytical Methods............................................................................................................ 287


    João Henrique Picado Madalena Santos, Carlos Miguel Nóbrega Mendonça,


    Francislene Andréia Hasmann, and Adalberto Pessoa Jr


    Chapter 19 Nanotechnology and Biopharmaceuticals..................................................................................................... 299


    Alexsandra Conceição Apolinário, Valker Araujo Feitosa, João Henrique Picado Madalena Santos,


    and Carlota de Oliveira Rangel-Yagui


    Chapter 20 Biosafety Applied in Pharmaceutical and Biotechnological Processes.........................................................313


    Camila Manoel Crnkovic, Celso Pereira Caricati, Ricardo Pinheiro de Souza Oliveira, and


    Marco Antonio Stephano


    Chapter 21 Pharmaceutical Quality System for Biotechnology Products........................................................................325


    Laura de Oliveira Nascimento, Francisco Vitor Santos da Silva, and Marco Antonio Stephano


    Chapter 22 Techno-Economic Evaluation of Biotechnological Processes and Pharmacoeconomic Analysis................355


    Rafael da Gama Ferreira, Nicola Sgrignoli Fuganholi, Larissa Pereira Brumano,


    Adriano Rodrigues Azzoni, and Sindelia Freitas


    Chapter 23 Perspectives for Pharmaceutical Biotechnology............................................................................................369


    Michele Vitolo

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