Human Genome Epidemiology by Khoury, Muin J.; Little, Julian; Burke, Wylie;

A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease

Sorozatcím: Monographs in Epidemiology and Biostatistics;

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Kiadó Oxford University Press
Megjelenés dátuma 2003. december 11.

ISBN 9780195146745
Kötéstípus Keménykötés
Terjedelem570 oldal
Méret 235x152x35 mm
Súly 1105 g
Nyelv angol
Illusztrációk 25 line illustrations and 6 halftone photographs

Kategóriák

Fertőző betegségek, mikrobiológia Genetika

Rövid leírás:

This book describes the important role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It proceeds systematically from the fundamentals of genome technology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services.

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Hosszú leírás:

Advances in genomics are expected to play a central role in medicine and public health in the future by providing a genetic basis for disease prediction and prevention. The transplantation of human gene discoveries into meaningful actions to improve health and prevent disease depends on scientific information from multiple disciplines, including epidemiology. This book describes the important role that epidemiologic methods play in the continuum from gene discovery to the
development and application of genetic tests. It proceeds systematically from the fundamentals of genome technology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services. These methodologic approaches
are then illustrated with several disease-specific case studies.

Több

Tartalomjegyzék:

Part I: Fundamentals
Human Genome Epidemiology: Scope and Strategies
Emerging Genomic Technologies and Analytic Methods for Population- and Clinic-Based Research
Approaches to Quantify the Genetic Component of and Identify Genes for Complex Traits
Ethical, Legal and Social Issues in the Design and Conduct of Human Genome Epidemiology Studies
Part II: Methods and Approaches I: Assessing Disease Associations and Interactions
Assessing Genotypes in Human Genome Epidemiology Studies
Statistical Issues in the Design and Analysis of Gene-Disease Association Studies
Facing the Challenge of Complex Genotypes and Gene-Environment Interaction: The Basic Epidemiologic Units in Case-Control and Case-Only Designs
Inference Issues in Cohort and Case-Control Studies of Genetic Effects and Gene-Environment Interactions
Applications of Human Genome Epidemiology to Environmental Health
Reporting and Review of Human Genome Epidemiology Studies
Part III: Methods and Approaches II: Assessing Genetic Tests for Disease Prevention
Epidemiologic Approach to Genetic Tests: Population-Based Data for Preventive Medicine
Genetic Tests in Populations: An Evidence Based Approach
ACCE: A Model Process for Evaluating Data on Emerging Genetic Tests
The Interface Between Epidemiology and Pharmacogenetics
Integrating Genetics Into Randomized Controlled Trials
Developing Guidelines for the Clinical Use of Genetic Tests: A US Perspective
Using Human Genome Epidemiologic Evidence in Developing Genetics Services: The UK Experience
Part IV: Case Studies: Using Human Genome Epidemiology Information to Improve Health
Paraoxonase Polymorphisms and Susceptibility to Organophosphate Pesticides
Factor V Leiden, Oral Contraceptives, and Deep Vein Thrombosis
Methylenetetrahydrofolate Reductase Gene (MTHFR), Folate, and Colorectal Neoplasia
Apolipoprotein E and Alzheimer Disease
Immunogenetic Factors in Chronic Beryllium Disease
Fragile X Syndrome: From Gene Identification to Clinical Diagnosis and Population Screening
The Connexin Connection: From Epidemiology to Criminal Practice
Genetic and Environmental Factors in Cardiovascular Disease
BRCA1/2 and the Prevention of Breast Cancer
The Role of Chemokine and Chemokine Receptor Genes in HIV-1 Infection
Hereditary Hemochromatosis
Genetic Testing of Railroad Track Workers with Carpal Tunnel Syndrome