Emerging Strategies in Antibacterial Drug Resistance Management: Mechanisms, Challenges, and Novel Interventions by Grewal, Ajmer Singh;

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This book is an in-depth and comprehensive resource that addresses the growing crisis of antimicrobial drug resistance (AMR). This book delves into the complexities of AMR, offering a detailed exploration of the mechanisms behind resistance, the environmental and genetic factors that facilitate it, and the broad ecological impacts it has. This book begins with an introduction to antimicrobial drug resistance, setting a foundational understanding of the scope and scale of the problem. It then progresses into a thorough analysis of the mechanisms by which microbes develop resistance, such as genetic mutations and the acquisition of resistance genes through horizontal gene transfer. A significant portion of the book is dedicated to examining the environmental and genetic factors associated with antimicrobial drug resistance. Additionally, the text explores the impact of antimicrobial drugs on micro-biodiversity, shedding light on how these drugs disrupt microbial communities and the balance of ecosystems. This book also considers the indirect effects of antimicrobial drugs on flora and fauna, emphasizing the far-reaching ecological consequences of widespread antimicrobial use. A central theme of the book is the exploration of emerging strategies in antibacterial drug resistance management. It discusses novel mechanisms and interventions that are being developed to combat resistance, highlighting the innovative approaches and the challenges they face. This book also explores anti-virulence therapeutic approaches that target the virulence factors of bacteria rather than their viability, thus reducing the selective pressure for resistance. Other cutting-edge strategies include targeting microbial biofilms, which are structured communities of bacteria that are particularly resistant to antibiotics and developing targeted drug delivery systems to enhance the efficacy of antimicrobial treatments. Natural products are another area of focus, with chapters dedicated to the potential of algal products and lantibiotics as alternatives to traditional antibiotics. Further, the book addresses the challenges of water and sanitation in relation to AMR, emphasizing the role of inadequate infrastructure and poor practices in the spread of resistant microbes. The influence of poultry farming on AMR is examined, highlighting the extensive use of antibiotics in agriculture and its impact on resistance patterns. Advanced topics include the application of computational biology and nanotechnology in the fight against AMR. Computational biology aids in the prediction and design of new antimicrobial agents, while nanotechnology-based approaches offer innovative solutions for overcoming bacterial defences. This book also touches on the implications of the COVID-19 pandemic on antimicrobial drug resistance, discussing how the pandemic has influenced resistance patterns and healthcare practices. It concludes by framing AMR as a global menace with significant social health and environmental implications, stressing the urgent need for coordinated global action. This book is an essential reference for researchers, healthcare professionals, and policymakers. It provides a holistic view of the AMR crisis and offers a diverse array of strategies to mitigate this critical global health threat.