Autoantibodies by Shoenfeld, Yehuda; Gershwin, M. Eric; Gershwin, M.E.;

Hosszú leírás:

Autoantibodies was published and presented in November 2006 at the International Congress of Autoimmunity in Sorrento, a small town in Campania, Italy. The Congress also celebrated the 100th anniversary of the first routine test for autoantibodies. An autoantibody is a type of antibody that is produced by the immune system and that fights one or more of a person's own proteins. These autoantibodies cause autoimmune diseases such as lupus erythematosus. The authors and editors of this book provide a critical review of autoantibodies and their primary functions. They cite a number of major developments in the field of autoantibodies, including the detection of autoantibodies in which a healthy person is a carrier; the discovery that autoantibodies can be both pathogenic and protective in some cases; and the development of a device that will help monitor and detect a specific autoantibody using a small amount of serum and proteomic arrays. Aside from the pathogenic and protective autoantibodies, the book also discusses irrelevant autoantibodies, as these may be relevant for future research. It also addresses the importance of the autoantibodies in a person's body. Clinical physicians, as well as scientists interested in the significance of autoantibodies in the human body, will find this book relevant. It will also be of interest to those who suffer from an autoimmune disease.

Tartalomjegyzék:

I Introduction: Autoantibodies-Unique Characteristics
1 What is an Autoantibody?
2 Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity
3 Molecular Mimicry
4 Affinity and Avidity of Autoantibodies
5 Pathogenic Mechanisms and Clinical Relevance of Autoantibodies
6 Native Autoantigens Versus Recombinant Autoantigens
7 Redox-Reactive Autoantibodies
8 Predictive Autoantibodies
9 Autoantibody Subclasses
10 Idiotypes and Anti-Idiotypes
11 Novel Diagnostic Methods for Autoantibody Detection

II Allergic Disease Autoantibodies
12 Human IgE-Specific Autoantibodies and Autoantibodies to IGE Receptors

III Antineutrophil Antibodies
13 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase
14 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Proteinase 3
15 Neutrophil-Specific Antinuclear and Anti-cytoplasmic Antibodies in Chronic Inflammatory Diseases
16 Antineutrophil Cytoplasmatic Autoantibodies with Specificity to Proteinase 3

IV Introduction: Antinuclear Antibodies
17 Antinuclear Antibodies: General Introduction
18 Antinucleolar Antibodies
19 Anti-Chromatin (Nucleosome) Autoantibodies
20 Centromere Autoantibodies
21 dsDNA Autoantibodies
22 Histone Autoantibodies
23 Ku and Ki Autoantibodies
24 Neuronal Nuclear Autoantibodies, Type 1 (HU)
25 Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies
26 Anti-Nucleosome Autoantibodies
27 Proliferating Cell Nuclear Antigen Autoantibodies
28 Anti-RA33 Antibodies (Antibodies to the Heterogeneous Nuclear Ribonucleoprotein A2)
29 Anti-Ribosomal P Antibodies
30 SS-A (Ro) Autoantibodies
31 Topoisomerase-I (Scl-70) Autoantibodies
32 SS-B (La) Autoantibodies
33 Anti-RNA Polymerase III Antibodies

V Autoantibodies to Biologic Factors/Structures
34 GW Bodies, P Bodies and Components of the miRNA Pathway
35 Golgi Complex and Endosome Antibodies
36 p53 Autoantibodies
37 Human Antiganglioside Autoantibodies
38 Human Anti--Galactosyl Antibodies
39 Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIG)
40 Cytokine Antibodies
41 Cytoskeletal Autoantibodies/Anti-Actin Antibodies
42 Fibrillarin Autoantibodies
43 Fibronectin Autoantibodies
44 Interferon-Inducible Protein IFI16 Autoantibodies

VI Cardiac Autoantibodies
45 Autoantibodies in Atherosclerosis
46 Heat Shock Protein Autoantibodies
47 Myocardial Autoantibodies and their Clinical Significance

VII Endocrine Autoantibodies
48 Glutamic Acid Decarboxylase Autoantibodies
49 Humoral Immunity in Type 1 Diabetes Mellitus
50 Antibodies to Adrenal, Gonadal Tissues and Steroidogenic Enzymes
51 Thyroglobulin, Thyroperoxidase, and Thyrotropin-Receptor Autoantibodies

VIII GI And Liver Autoantibodies
52 Anti-Intestinal Goblet Cell Antibodies
53 Tumor-Associated Autoantibodies
54 Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection
55 Anti-Tissue Transglutaminase and Anti-Endomyisial Antibodies
56 Anti-Gliadin Antibodies
57 Reticulin Autoantibodies
58 Liver Cytosol Antigen Type 1 Autoantibodies, Liver Kidney Microsomal Autoantibodies, and Liver Microsomal Autoantibodies
59 Antimitochondrial Antibodies
60 Parietal Cell and Intrinsic Factor Autoantibodies
61 Smooth Muscle Antibodies

IX Hematologic Autoantibodies
62 Coagulation Factor Autoantibodies
63 Autoantibodies in Heparin-Induced Thrombocytopenia
64 Platelet Autoantibodies
65 Red Cell Autoantibodies
66 Lymphocytotoxic Autoantibodies

X Kidney Autoantibodies
67 Anti-ATP Synthase ?-Chain Autoantibodies
68 Glomerular Basement Membrane Autoantibodies
69 Nephritic Factor Autoantibodies

XI Neurological System Autoantibodies
70 Acetylcholine Receptor and Muscle Specific Kinase Autoantibodies
71 Myositis Autoantibodies: Aminoacyl-tRNA Synthetase, Signal Recognition Particle, Mi-2, and PM-Scl Autoantibodies
72 Anti-MOG Antibodies
73 Antibodies to Hsp 70 in Inner Ear Disease
74 Autoantibodies in the Lambert-Eaton Myasthenic Syndrome (LEMS) and Amyotrophic Lateral Sclerosis (ALS)
75 Ganglioside Autoantibodies
76 Myelin Associated Antibodies: Myelin-Associated Glycoprotein Autoantibodies, Myelin Basic Protein Autoantibodies and Myelin Proteolipid Autoantibodies in Neurologic Diseases
77 Paraneoplastic Neurological Antibodies: Nuclear
78 Paraneoplastic Neurological Antibodies: Purkinje Cell Cytoplasm
79 Paraneoplastic Neurological Antibodies: Additional Reactivities
80 Retinal Autoantibodies
81 Autoantibodies in Epilepsy

XII Rheumatic Disease Autoantibodies
82 Anti-Fodrin Antibodies
83 Antibodies to Laminin
84 Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjï¿1⁄2gren's Syndrome
85 ?2-Glycoprotein I Autoantibodies
86 C1 Inhibitor Autoantibodies
87 Autoantibodies to C1q
88 Anti-Collagen Antibodies
89 Anti-Cyclic Citrullinated Peptide Antibody
90 Anti-Endothelial Cell Autoantibodies
91 Lupus Anticoagulant Testing
92 Anticardiolipin Antibodies
93 Phospholipid Autoantibodies (Non-Anticardiolipin)-Anti-Prothrombin Antibodies
94 Rheumatoid Factors

XIII Skin Disease Autoantibodies
95 Autoantibodies to Mucocutaneous Antigens

XIV Unique Clinical Situations
96 Autoimmunity and the Newer Biopharmaceuticals
97 Autoantibodies Against Tumor Suppressor Proteins
98 Detection of Autoantibodies Using Protein Arrays
99 Autoantibodies and Pregnancy Loss

XV Future Directions
100 Anti-Glycan Antibodies
101 Future Trends