Anticancer Agents from Natural Products by Cragg, Gordon M.; Kingston, David G. I.; Newman, David J.;

Rövid leírás:

This book covers clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. The second edition includes drugs that are currently in development. In addition, the text emphasizes the applications of synthetic and medicinal chemistry to the preparation of analogs with enhanced activities.

Hosszú leírás:

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the:

• History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications
• Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery
• Important biosynthetic approaches to "unnatural" natural products

Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future.

Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

"…maintains the extremely high standards of the first edition…. Over the past few years, a comparatively large number of anticancer agents of natural product origin have been brought to the market, so this expanded and updated volume is of very high relevance to members of the biomedical research community. The authors and editors of this second edition deserve heartfelt congratulations for compiling such an informative and inspiring volume, which serves as a major addition to the natural products literature."
—A. Douglas Kinghorn, The Ohio State University, Columbus, in Journal of Natural Products

Praise for the Previous Edition

"The book brings home to us not only the amazing chemical complexity of the natural world but also the vast reservoir of potential new healing agents that yet remain to be tapped. This impressive work, which maintains a uniformly high standard throughout, will be of major benefit to a wide readership… .It seems likely that it will remain the definitive work in its genre for many years to come."
—Chemistry World

"Edited by leading scientists who have contributed enormously to natural product development and potential anticancer natural products, Anticancer Agents from Natural Products is a convenient summary of the current status of research and development of some of the most effective anticancer agents available today. It is an ideal foundation for scientist engaged in developing new and improved drugs based on natural sources."
—Memoriile Sectiilor Stintifice

Tartalomjegyzék:

PLANT PRODUCTS: Introduction. Camptothecin and its Analogs. Discovery and Development of the Combretastatins. Homoharringtonine and Related Compounds. Podophyllotoxins and Analogs. Taxol and Its Analogs. The Vinca Alkaloids. MARINE PRODUCTS: The Bryostatins. The Cryptophycins. The Discodermolides. The Dolastatins. Ecteinascidin-743. Aplidin. Kahalalide F. Discovery of E7389. Synthetic Halichondrin Analog.HTI-286. Synthetic Analog of Hemiasterlins. Salinosporamide etc. MICROBIAL PRODUCTS: The Actinomycins. The Anthracyclines. Ansamitocins (Maytansanoids). Benzoquinone Ansamycins. The Bleomycin Group. Biochemical Evaluation of CC1065 Analogs. Epothilone, A Myxobacterial Metabolite. Enediynes Biosyntheses. The Mitomycins. Staurosporines and Related Compounds. Potential for New Compounds from Gene Analyses (Bacterial and Fungal). Environmental DNA. MISCELLANEOUS DEVELOPMENTS: Combinatorial Biosynthesis. Developments and Future Trends.