Repeat Amino Acid Sequences in Proteins by N. Uversky, Vladimir; Gupta, Munishwar Nath;

Rövid leírás:

This volume highlights the use of residue cluster classes to represent proteins structure and model structure-function relationships. It explores the role of aromatic amino acid clusters in protein-protein and protein-drug interactions. It highlights the cell-penetrating peptides and Elastin-like peptide.

Hosszú leírás:

Repeat amino acid sequences are important in protein structure, disorder, function and evolution. Repeats of some amino acids exist in proteomes across species.

This volume highlights:

• Which repeat sequences have pathogenic consequences and why?


• Repeats which lead to surface hydrophobic clusters and their importance


• Role of aromatic amino acid clusters in protein‐protein and protein‐drug interactions


• Cell‐penetrating peptides and Elastin‐like peptides


• Unusual phenomenon of fluorescence observed with repeats of some non‐aromatic amino acids


• The use of residue cluster classes to represent protein structure and model structure‐function relationships.

Tartalomjegyzék:

Preface. 1. Pathogenic Role of Repeat Polypeptides in Repeat Expansion Diseases. 2. Pathologies Due to PolyQ Sequences. 3. Importance of Surface Hydrophobic Clusters in Proteins. 4. Residue Cluster Classes in Protein-Protein Interactions. 5. Aromatic Clusters in Proteins: Folding, Drug Interactions and Protein-Protein Complexes. 6. Cell Penetrating Peptides with Repeat Sequences of Amino Acids. 7. Recent Advances and Applications in Self-Assembling Short-Chain Elastin-Like Peptide Analogs. 8. Unconventional Fluorescence Properties of Non-aromatic Amino Acids: Material and Biological Applications. Index.