Renal Physiology by Koeppen, Bruce M.; Stanton, Bruce A.;

Mosby Physiology Monograph Series (with Student Consult Online Access)

Sorozatcím: Mosby's Physiology Monograph;

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Kiadás sorszáma 4
Kiadó Mosby
Megjelenés dátuma 2006. szeptember 13.

ISBN 9780323034470
Kötéstípus Puhakötés
Terjedelem248 oldal
Méret 235x191 mm
Súly 472 g
Nyelv angol
Illusztrációk Approx. 100 illustrations

Kategóriák

Fiziológia, élettan, anyagcsere Vesebetegségek, nephrológia

Rövid leírás:

Introduces physiology relevant to a particular organ system. This book offers coverage of the physiology of the renal system; pathophysiology content that serves as a bridge between normal function and disease; and, tools, including learning objectives, overview boxes, key words and concepts, chapter summaries, self-study problems, and more.

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Hosszú leírás:

The Mosby Physiology Monograph Series offers the fundamentals of body systems physiology in a clear and concise manner. Each volume in the series is written by experts in the field for an authoritative, yet readable introduction to the physiology relevant to a particular organ system.

This new 4th edition of Renal Physiology offers:

. Clear, accurate and up-to-the-minute coverage of the physiology of the renal system focusing on the needs of the student.
. Pathophysiology content throughout that serves as a bridge between normal function and disease.
. Integrated student-friendly tools, including learning objectives, overview boxes, key words and concepts, chapter summaries, self-study problems, clinical cases with questions and explained answers, clinical boxes and molecular boxes.
. Access to Student Consult ?!

www.studentconsult.com is an innovative website that allows you to build a personalized, fully integrated, online library, where you'll find the entire contents of every STUDENT CONSULT title purchased, integration links to bonus content in other STUDENT CONSULT titles, and much more.

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Tartalomjegyzék:

Introduction to the Kidney

1Physiology of Body Fluids

OBJECTIVES
PHYSICOCHEMICAL PROPERTIES OF ELECTROLYTE SOLUTIONS
Molarity and Equivalence
Osmosis and Osmotic Pressure
Osmolarity and Osmolality
Tonicity
Oncotic Pressure
Specific Gravity
VOLUMES OF BODY FLUID COMPARTMENTS
COMPOSITION OF BODY FLUID COMPARTMENTS
FLUID EXCHANGE BETWEEN BODY FLUID COMPARTMENTS
Capillary Fluid Exchange
Cellular Fluid Exchange
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

2Structure and Function of the Kidneys

OBJECTIVES
STRUCTURE OF THE KIDNEYS
Gross Anatomy
Ultrastructure of the Nephron
Ultrastructure of the Renal Corpuscle
Ultrastructure of the Juxtaglomerular Apparatus
Innervation of the Kidneys
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

3Glomerular Filtration and Renal Blood Flow

OBJECTIVES
RENAL CLEARANCE
Glomerular Filtration Rate
GLOMERULAR FILTRATION
Determinants of Ultrafiltrate Composition
Dynamics of Ultrafiltration
RENAL BLOOD FLOW
REGULATION OF RENAL BLOODS FLOW AND GLOMERULAR FILTRATION RATE
Sympathetic Nerves
Angiotensin II
Prostaglandins
Nitric Oxide
Endothelin
Bradykinin
Adenosine
Natriuretic Peptides
ATP
Glucocorticoids
Histamine
Dopamine
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

4Renal Transport Mechanisms: NaCl and Water Transport Along the Nephron

OBJECTIVES
GENERAL PRINCIPLES OF MEMBRANE TRANSPORT
GENERAL PRINCIPLES OF TRANSEPITHELIAL SOLUTE AND WATER TRANSPORT
NaCl, SOLUTE, AND WATER REABSORPTION ALONG THE NEPHRON
Proximal Tubule
Henle's Loop
Distal Tubule and Collecting Duct
REGULATION OF NaCL AND WATER REABSORPTION
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

5Regulation of Body Fluid Osmolality: Regulation of Water Balance

OBJECTIVES
ANTIDIURETIC HORMONE
Osmotic Control of ADH Secretion
Hemodynamic Control of ADH Secretion
ADH Actions on the Kidneys
THIRST
RENAL MECHANISMS FOR DILUTION AND CONCENTRATION OF THE URINE
Medullary Interstitium
Vasa Recta Function
ASSESSMENT OF RENAL DILUTING AND CONCENTRATING ABILITY
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

6Regulation of Extracellular Fluid Volume and NaCl Balance

OBJECTIVES
CONCEPT OF EFFECTIVE CIRCULATING VOLUME
VOLUME-SENSING SYSTEMS
Vascular Low-Pressure Volume Sensors
Vascular High-Pressure Volume Sensors
Hepatic Sensors
Central Nervous System Na+ Sensors
Volume Sensor Signals
Renal Sympathetic Nerves
Renin-Angiotensin-Aldosterone System
Natriuretic Peptides
Antidiuretic Hormone
CONTROL OF RENAL NaCL EXCRETION DURING EUVOLEMIA
Mechanisms for Maintaining the Delivery of Na+ to the Distal Tubule Constant
Regulation of Distal Tubule and Collecting Duct Na+ Reabsorption
CONTROL OF Na+ EXCRETION WITH VOLUME EXPANSION
CONTROL OF Na+ EXCRETION WITH VOLUME CONTRACTION
EDEMA
Alterations in Starling Forces
The Role of the Kidneys
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

7Regulation of Potassium Balance

OBJECTIVES
OVERVIEW OF K+ HOMEOSTASIS
REGULATION OF PLASMA [K+]
Epinephrine
Insulin
Aldosterone
ALTERATIONS OF PLASMA [K+]
Acid-Base Balance
Plasma Osmolality
Cell Lysis
Exercise
K+ EXCRETION BY THE KIDNEYS
CELLULAR MECHANISMS OF K+ SECRETION BY PRINCIPAL CELLS IN THE DISTAL TUBULE AND COLLECTING DUCT
REGULATION OF K+ SECRETION BY THE DISTAL TUBULE AND COLLECTING DUCT
Plasma [K+]
Aldosterone
Antidiuretic Hormone
FACTORS THAT PERTURB K+ EXCRETION
Flow of Tubular Fluid
Acid-Base Balance
Glucocorticoids
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

8Regulation of Acid-Base Balance

OBJECTIVES
THE HCO3- BUFFER SYSTEM
OVERVIEW OF ACID-BASE BALANCE
NET ACID EXCRETION BY THE KIDNEYS
HCO3- REABSORPTION ALONG THE NEPHRON
REGULATION OF H+ SECRETION
Formation of New HCO3-
RESPONSE TO ACID-BASE DISORDERS
Extracellular and Intracellular Buffers
Respiratory Compensation
Renal Compensation
SIMPLE ACID-BASE DISORDERS
Metabolic Acidosis
Metabolic Alkalosis
Respiratory Acidosis
Respiratory Alkalosis
ANALYSIS OF ACID-BASE DISORDERS
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

9Regulation of Calcium and Phosphate Homeostasis

OBJECTIVES
CALCIUM
Overview of Ca++ Homeostasis
Ca++ Transport along the Nephron
Regulation of Urinary Ca++ Excretion
Calcium-Sensing Receptor
PHOSPHATE
Overview of Pi Homeostasis
Pi Transport along the Nephron
Regulation of Urinary Pi Excretion
INTEGRATIVE REVIEW OF PARATHYROID HORMONE, CALCITRIOL, AND CALCITONIN ON Ca++ AND PI HOMEOSTASIS
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

10Physiology of Diuretic Action

OBJECTIVES
GENERAL PRINCIPLES OF DIURETIC ACTION
Sites of Action of Diuretics
Response of Other Nephron Segments
Adequate Delivery of Diuretics to Their Site of Action
Volume of the Extracellular Fluid
DIURETIC BRAKING PHENOMENON
MECHANISMS OF ACTION OF DIURETICS
Osmotic Diuretics
Carbonic Anhydrase Inhibitors
Loop Diuretics
Thiazide Diuretics
K+-Sparing Diuretics
Aquaretics
EFFECT OF DIURETICS ON THE EXCRETION OF WATER AND OTHER SOLUTES
Solute-Free Water
K+ Excretion
HCO3- Excretion
Ca++ and Pi Excretion
SUMMARY
KEY WORDS AND CONCEPTS
SELF-STUDY PROBLEMS

Additional Reading

APPENDIX A Integrative Case Studies

APPENDIX B Normal Laboratory Values

APPENDIX C Nephron Function

APPENDIX D Answers to Self-Study Problems

APPENDIX E Answers to Integrative Case Studies

APPENDIX F Review Examination

Index