Cancer Immunology and Immunotherapy by Amiji, Mansoor M.; Milane, Lara Scheherazade;

Volume 1 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy

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Kiadó Elsevier Science
Megjelenés dátuma 2021. augusztus 27.

ISBN 9780128233979
Kötéstípus Puhakötés
Terjedelem548 oldal
Méret 234x190 mm
Súly 1130 g
Nyelv angol
Illusztrációk 120 illustrations (84 in full color)

Kategóriák

Hosszú leírás:

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapyï¿1⁄2examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited.

Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches.

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

Több

Tartalomjegyzék:

1. The hallmarks of cancer and immunology
2. Innate and adaptive immunity in cancer
3. Inflammation and cancer
4. Novel immunotherapeutic approaches to cancer: Voltage-gated sodium channel expression in immune cells and tumors
5. Immunoediting and cancer priming
6. Metabolic reprogramming and immunity in cancer
7. Epigenetic programming of the immune responses in cancer
8. Cellular therapeutics in immuno-oncology
9. T-cell engaging bispecific antibody therapy
10. Role of microbiome in cancer immunotherapy
11. STING pathway and modulation for cancer immunotherapy
12. Oncolytic viruses in immunotherapy
13. Comparison of therapeutic strategies for immuno-oncology
14. Intrinsic and acquired cancer immunotherapy resistance
15. Preclinical and clinical toxicity of immuno-oncology agents and mitigation strategies

Több

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