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  • Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach

    Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment by Libon, David J.; Lamar, Melissa; Swenson, Rodney A.;

    Advancing an Integrated Approach

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    A termék adatai:

    • Kiadó OUP USA
    • Megjelenés dátuma 2020. április 22.

    • ISBN 9780190634230
    • Kötéstípus Keménykötés
    • Terjedelem504 oldal
    • Méret 239x160x35 mm
    • Súly 839 g
    • Nyelv angol
    • 0

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    Rövid leírás:

    The focus of this edited volume is to examine how Alzheimer's disease and vascular dementia, as well as their mild cognitive impairment analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical neuropsychologists and anyone studying or treating dementia in its many forms.

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    Hosszú leírás:

    Alzheimer's disease (AD) and vascular dementia (VaD) are commonly viewed as the first and second most common types of dementia, respectively. The traditional paradigm has been to view and treat each illness as a separate entity with a separate pathophysiology. However, clinical and pathological studies suggest that the boundary separating AD and VaD, as well as their mild cognitive impairment (MCI) analogs, is not well defined. Thus, there is increased interest in viewing these diseases along a spectrum because of the significant overlap in the characterization and diagnosis of AD, VaD, and MCI. The focus of this edited volume is to examine how AD and VaD, as well as their MCI analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical neuropsychologists and anyone studying or treating dementia in its many forms.

    A 'must-read,' very timely, comprehensive interdisciplinary overview illuminating the complexity of the dementia syndromes, particularly Vascular-Alzheimer spectrum disorders."
    -Sandra E. Black, Professor of Medicine (Neurology), Department of Medicine, Sunnybrook HSC and University of Toronto

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    Tartalomjegyzék:

    Preface
    Part 1: Epidemiology and Neuropsychology
    Chapter 1: Vascular risk factors and their relationship to brain aging: Findings from the Framingham Heart Study
    Chapter 2: Neuropsychological Profiles in Alzheimer's/ Vascular Spectrum Dementia
    Chapter 3: Neuropsychological Diagnostic Criteria for Mild Cognitive Impairment due to Alzheimer's Disease
    Chapter 4: Vascular Cognitive Impairment
    Chapter 5: Decline in Everyday Functioning in MCI and Dementia: A Neuropsychological Perspective
    Chapter 6: Heterogeneity in Dementia and MCI: Using Statistical Modeling Techniques
    Chapter 7: Apraxic and Action-Intentional Disorders Associated With Vascular And Degenerative Dementing Diseases
    Part 2: Neuroimaging
    Chapter 8: Cerebral small vessel disease and the risk of dementia and cognition decline
    Chapter 9: Structural MRI in Alzheimer's disease: Are we measuring the right stuff
    Chapter 10: Advances in Multi-Modal Imaging Across the Spectrum of Normal to Pathological aging: Incorporating Vascular Comorbidities Common to Alzheimer's disease and Vascular Dementia
    Part 3: Blood-Brain-Barrier and Cardiogenic Mechanisms
    Chapter 11: The Blood-Brain Barrier in Cognitive Decline and Alzheimer's Disease
    Chapter 12: Arterial Stiffening and Cerebrovascular Resistance in Cognitive Decline and Alzheimer's Disease
    Chapter 13: Hemodynamics in Alzheimer's Disease and Vascular Cognitive Impairment & Dementia
    Part 4: Neuropathological and Neurophysiological Mechanisms
    Chapter 14: Neuropathology of AD/ VaD Dementia
    Chapter 15: Potential of blood- and CSF-based biomarkers for AD diagnostics
    Chapter 16: Unravelling the Role of Mitochondria in Alzheimer's disease: Toward Assembling the Puzzle
    Part 5: Treatment and Intervention
    Chapter 17: Dementia and Elective Surgeries: Considerations for Neuropsychologists
    Chapter 18: Management of Mild Cognitive Impairment

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