Petri Nets in Systems Biology by Bashirov, Rza;

Methodology and Applications

Sorozatcím: Advances in Experimental Medicine and Biology;

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Beszerezhetőség

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A termék adatai:

Kiadó Springer Nature Switzerland
Megjelenés dátuma 2026. május 23.

ISBN 9783032200402
Kötéstípus Keménykötés
Terjedelem113 oldal
Méret 254x178 mm
Nyelv angol
Illusztrációk XXIV, 113 p. 63 illus., 31 illus. in color.

Kategóriák

Szerves kémia Az orvostudomány általános kérdései Gyógyszerészet Genetika

Hosszú leírás:

Petri Nets in Systems Biology presents a rigorous and coherent framework for modeling and analyzing complex biological systems. Positioned at the intersection of computer science, biomedicine, bioinformatics, and target-based drug discovery, the book demonstrates how Petri nets naturally capture key characteristics of biological processes, including concurrency, synchronization, causality, stochastic, and fuzzy behavior.

The book introduces fundamental Petri net concepts and progressively extends them to address core problems in systems biology, such as the modeling of metabolic networks, gene regulatory systems, signal transduction pathways, and cellular control mechanisms. Both qualitative and quantitative analysis techniques are covered, including invariant analysis, reachability, structural properties, stochastic modeling, and hybrid extensions.

A strong emphasis is placed on modularity, compositional modeling, and biological interpretability, enabling readers to construct scalable and reusable models that remain closely aligned with underlying biological knowledge. Through carefully selected running examples and case studies, the book illustrates how Petri net technologies can be used to simulate system dynamics, analyze regulatory structure, and gain insight into emergent behaviors of complex biological networks.

Intended for researchers, graduate students, and advanced practitioners, Petri Nets in Systems Biology serves as both an accessible introduction and a comprehensive reference. It provides the theoretical foundations and practical tools necessary for applying Petri nets to contemporary challenges in computational and systems biology.

Presents easy-to-explain and easy-to-understand solution to the first stage of target-based drug discovery

Novel approach as book is one of the first to apply Petri nets in target-based drug and gene therapies

Equally useful for wide-spectrum of researchers from computer scientists and Petri netters to molecular biologists and experts in pharmacogenetics

Több

Tartalomjegyzék:

Part I: Methodology.- Petri Nets.- Modeling with Petri Nets.- Part II: Applications.- Target-Based Discovery of Drug Combinations for Spinal Muscular Atrophy.- Modeling Therapeutic Targets: β-globin Disorders and Beyond.- Behavior Prediction in Signaling Networks: Modeling of p16-Mediated Pathway.- Understanding Behavior of Biological Networks with Invariant Computation.- Index.