Gasotransmitters in Organ Transplantation by Dugbartey, George J.;

Hosszú leírás:

This book covers recent pre-clinical and clinical developments in gasotransmitters (nitric oxide, carbon monoxide and hydrogen sulfide) in all transplantable solid organs – kidney, heart, lung, liver, pancreas and intestine. Gasotransmitters are a class of small endogenously produced gaseous signaling molecules that play important roles in cellular homeostasis and impact physiological and pathophysiological situations. Recently, these gasotransmitters have emerged as potent cytoprotective mediators, possessing therapeutic properties that enable them exhibit their intracellular signaling functions. Hence, alterations in their physiological levels have been associated with various pathologies including cold ischemia-reperfusion injury (IRI) in organ transplantation.

In the context of organ transplantation, a novel therapeutic strategy that is being investigated involves administration of these gasotransmitters to the organ donor or recipient before or after transplantation, or supplementation of standard preservation solution with gasotransmitters during organ graft preservation to mitigate transplant-induced IRI. The book is divided into three parts for easier access: Hydrogen Sulfide in Organ Transplantation, Carbon Monoxide in Organ Transplantation, and Nitric Oxide in Organ Transplantation.

The proposed book presents recent advances in organ graft protection mediated by gasotransmitters against warm and cold IRI in preclinical models of organ transplantation and some selected clinical cases, and seeks to lay the foundation for future clinical applications of these gases. The book is topical and timely, and will serve as a good resource for both educational and didactic purposes in transplant patient care and other aspects of clinical medicine.

Tartalomjegyzék:

PART I: Hydrogen Sulfide in OrganTransplantation.- Chapter 1: Gasotransmitters.- Chapter 2: Pharmacological Modification of Organ Preservation Solution with Hydrogen Sulfide for Improved Kidney Transplantation Outcome.- Chapter 3: Hydrogen Sulfide Donor Molecules against Cold Ischemia-Reperfusion Injury in Preclinical Models of Solid Organ Transplantation.- Chapter 4: Pre-Treatment of Transplant Donors with Hydrogen Sulfide to Protect against Warm and Cold Ischemia-Reperfusion Injury in Kidney and Other Transplantable Solid Organ Grafts.- PART II: Carbon Monoxide in Organ Transplantation.- Chapter 5: Application of Carbon Monoxide in Kidney and Heart Transplantation: A Novel Pharmacological Strategy for a Broader Use of Suboptimal Renal and Cardiac Grafts.- Chapter 6: Carbon Monoxide as an Emerging Pharmacological Tool to Improve Lung and Liver Transplantation Protocols.- Chapter 7: Emerging Role of Carbon Monoxide in Intestinal Transplantation.- Chapter 8: Carbon Monoxide in Pancreatic Islet Transplantation: A New Therapeutic Alternative to Patients with Severe Type 1 Diabetes Mellitus.- PART III: Nitric Oxide in Organ Transplantation.- Chapter 9: Protective Role of Nitric Oxide in Kidney and Heart Transplantation.- Chapter 10: Beneficial Effects of Nitric Oxide in Lung and Liver Transplantation.- Chapter 11: Therapeutic Potential of Nitric Oxide in Pancreas and Intestinal Transplantation.