GABAb Receptor Pharmacology: A Tribute to Norman Bowery

Sorozatcím: Advances in Pharmacology; 58;

10% KEDVEZMÉNY?
A kedvezmény csak az 'Értesítés a kedvenc témákról' hírlevelünk címzettjeinek rendeléseire érvényes.

Kiadói listaár EUR 205.00
Az ár azért becsült, mert a rendelés pillanatában nem lehet pontosan tudni, hogy a beérkezéskor milyen lesz a forint árfolyama az adott termék eredeti devizájához képest. Ha a forint romlana, kissé többet, ha javulna, kissé kevesebbet kell majd fizetnie.

85 023 Ft (80 975 Ft + 5% áfa)
Kedvezmény(ek) 10% (cc. 8 502 Ft off)
Kedvezményes ár 76 521 Ft (72 878 Ft + 5% áfa)

85 023 Ft

Beszerezhetőség

Megrendelésre a kiadó utánnyomja a könyvet. Rendelhető, de a szokásosnál kicsit lassabban érkezik meg.

A termék adatai:

Kiadó Elsevier Science
Megjelenés dátuma 2010. szeptember 21.

ISBN 9780123786470
Kötéstípus Keménykötés
Terjedelem520 oldal
Méret 228x152 mm
Súly 790 g
Nyelv angol

Kategóriák

Idegtudomány Farmakológia, terapeutika, toxikológia Gyógyszerészet Ideggyógyászat, neurológia

Hosszú leírás:

This monograph was assembled to honor Professor Norman Bowery and his work on the 30^th anniversary of his discovery of the GABA_Breceptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABA_B receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABA_Bagonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABA_B activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse.

The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.

Több

Tartalomjegyzék:

1. Historical Perspective and Emergence of the GABA_B Receptor
Norman Bowery
2. Chemistry of GABA_B Receptor Ligands
Wolfgang Froestl
3. Heterodimerization of the GABA_B Receptor - Implications for GPCR Signaling and Drug Discovery
Fiona H. Marshall and Steven M. Foord
4. Mechanisms of GABA_B Receptor Exocytosis, Endocytosis and Degradation
Deitmar Benke
5. Functional Modulation of GABA_B Receptors by Protein Kinases and Receptor Trafficking
Miho Terunuma, Andres Couve, Menelas N. Pangalos, and Stephen J. Moss
6. GABA_B Receptor Coupling to G Proteins and Ion Channels
Claire Padgett and Paul A. Slesinger
7. GABA_B Receptor-mediated Modulation of Metabotropic Glutamate Signaling and Synaptic Plasticity in Central Neurons
M. Kano and Toshihide Tabata
8. GABA Transporter GAT1: A Crucial Determinant of GABA_B Receptor Activation in Cortical Circuits?
Guillermo Gonzalez-Burgos
9. The Role of GABA_B Receptors in Cortical Network Activity
Michael M. Kohl and Ole Paulsen
10. GABA_B Receptors: Physiology Functions and Mechanisms of Diversity
Andree Pinard, Riad Seddik, and Bernhard Bettler
11. Role of GABAB Receptors in Autonomic Control of Systemic Blood Pressure
De-Pei Li and Hui-Lin Pan
12. GABA_B Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease
Anders Lehmann, Jorgen Jensen, and Guy E. Boeckxstaens
13. GABA_B Receptors in Reward Processes
Styliani Vlachou and Athina Markou
14. GABA_B Receptors in Addiction and Its Treatment
David J. Nutt, Anne Lingford-Hughes, Laurence John Reed, and Robin J. Tyacke
15. GABA_B - GIRK2 Mediated Signaling in Down Syndrome
Nathan Cramer, Tyler Best, and Zygmunt Galdzicki
16. GABA_B Receptors and Depression: Current Status
John F. Cryan and David A. Slattery
17. GABA_B Receptors in Drosophila
Hari Manev and Svetlana Dzitoyeva