Cancer Vaccination and Challenges by Malviya, Rishabha; Prajapati, Bhupendra; Sundram, Sonali;

Short description:

Focuses cancer vaccines and their development and delivery, discussing techniques and the roles of tumor antigens, proteins/peptides, microbial genes, stem cells. It provides the latest insights on DNA- and RNA-based cancer vaccines. Vol 2 discusses delivery of cancer vaccines for the management of various cancers.

Long description:

Extensive attempts for developing cancer vaccines over the last 50 years have been made, but with minimal success. The current research in genetics, molecular biology, biochemistry, and immunology has revived interest in these immunotherapies and enabled the development of potential cancer vaccine candidates. This book, Cancer Vaccination and Challenges, in two volumes, deals with the very relevant issue of cancer vaccines and the various challenges their development and delivery present.

Volume 1: Different Strategies for Therapeutic Cancer Vaccine Development deals with different strategies of cancer vaccine development. The primary focus of this volume is the techniques for the development of therapeutic cancer vaccines. It helps clarify the current need for vaccines in cancer treatment, exploring deeper information such as the roles of tumor antigens, proteins/peptides, microbial genes, and stem cells for the development of vaccines for cancer management. The volume also provides latest insights on DNA- and RNA-based cancer vaccines, eventually covering the regulatory perspectives for the cancer vaccine developments.

Volume 2: Delivery Strategies for Cancer Vaccine and Immunotherapy in Management of Various Carcinomas presents an understanding of delivery strategies of cancer vaccines for the management of various forms of carcinoma. It discusses the management of various carcinomas using vaccines, examining the prospects of delivering immuno-oncology therapies, focusing specifically on the affective drug delivery strategies for treatment of lung, prostate, and pancreatic carcinomas. The volume provides an overview of the current vaccine systems, adjuvants, and delivery methods that are being explored or have been approved. It also focuses on therapeutic cancer vaccines that could be used to prevent the spread of advanced malignancies that are resistant to standard treatments, including surgery, radiation therapy, and chemotherapy.

This two-volume book will be a valuable resource for researchers with a pharmaceutical background and professionals working in the field of biomedical science, engineering, vaccine development, and cancer therapy.

“A comprehensive guide to cancer vaccine research. . . . cover[s] every aspect of cancer immunology and vaccine development . . . and explores the most successful and promising approaches by incorporating the latest studies on preventive and therapeutic cancer vaccination. The book offers up-to-date information on various topics, including tumor antigens for cancer vaccines, strategies, approaches, advancements, difficulties, and challenges in vaccine development for cancer treatment. Recent advances in DNA and RNA-based vaccines for cancer prevention and treatment are thoroughly discussed in this volume. This compendium enables researchers and practitioners to easily access the comprehensive concept of cancer vaccines and their implications in healthcare. . . . An essential resource in disseminating the vast and expanding literature on cancer immunization and vaccine development.”
—From the Foreword by Harish Padh, Former Vice-Chancellor, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat, India; Former Director, B. V. Patel Pharmaceutical Education and Research Development (PERD), Ahmedabad, Gujarat, India

Table of Contents:

VOLUME 1: DIFFERENT STRATEGIES FOR THERAPEUTIC CANCER VACCINE DEVELOPMENT 1. Cancer Vaccines: Types, Mechanisms, and Recent Developments 2. Strategies to Develop Cancer Vaccines 3. Role of Tumor Antigens for Cancer Vaccine Development 4. DNA-Based Cancer Vaccine: Advancements and Challenges 5. RNA-Based Cancer Vaccines: Advancements and Challenges 6. Utilization of Microbial Genes as a Vaccine Against Cancer 7. Utilization of Protein and Peptides as Cancer Vaccines: Advancements and Challenges 8. Stem Cell-Based Cancer Vaccines as Promising Immunotherapy: Current Progress and Challenges 9. Preventive Cancer Vaccines 10. Providing Cognitive Platforms for the Effectiveness of Cancer Vaccines 11. Survival Data and Therapeutic Outcomes of Cancer Vaccines 12. Regulatory Considerations for Cancer Vaccines Development VOLUME 2: DELIVERY STRATEGIES FOR CANCER VACCINES AND IMMUNOTHERAPY IN THE MANAGEMENT OF VARIOUS CARCINOMAS 1. Delivery Systems for Cancer Vaccines 2. Current Knowledge and Prospects of Various Vaccine Delivery Systems for Lung Cancer Treatment 3. Advanced Drug Delivery System for Targeting Carcinomas 4. Correlation Between Cancer Vaccines and Immunity 5. Cancer Vaccines for Lung Cancer 6. Synergistic Effect of Vaccines and Chemotherapeutic Agents in Combating Different Carcinomas 7. Cancer Immunotherapy Using mRNA 8. Autologous Vaccines for Prostate and Pancreatic Cancer 9. Combined Therapy of Cancer with Vaccines and Chemotherapeutic Agents 10. Role of Various Cancer Vaccine Adjuvants in Cancer Management 11. Combined Therapy of Cancer with Vaccines and Chemotherapeutic Agents