Antiseptic Stewardship by Kampf, Günter;

Biocide Resistance and Clinical Implications

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Product details:

Edition number 1st ed. 2018
Publisher Springer
Date of Publication 5 September 2018
Number of Volumes 1 pieces, Book

ISBN 9783319987842
Binding Hardback
No. of pages694 pages
Size 235x155 mm
Weight 1262 g
Language English
Illustrations 3 Illustrations, black & white; 17 Illustrations, color

Short description:

VVarious antiseptic agents, such as chlorhexidine, are used for different applications, e.g. in healthcare, veterinary medicine, animal production and household products, including cosmetics. However, not all antiseptic agents provide significant health benefits, especially in some products used in human medicine (alcohol-based hand rubs, antimicrobial soaps). While some products (antimicrobial soaps, surface disinfectants, instrument disinfectants, wound antiseptics) may contain one or more biocidal agents with a comparable antimicrobial efficacy but large differences in their potential for microbial adaptation and tolerance. An increased bacterial resistance has been described for various antimicrobial agents, sometimes including a cross-resistance to antibiotics.

The book is the first comprehensive reference resource on antiseptic agents, including their efficacy, natural and acquired resistance, adaptation, and cross-resistance. It also discusses their and appropriate use in terms of a balance between their efficacy and the risk of acquired bacterial resistance / tolerance. Focusing on human and veterinary medicine and household products, it helps readers make informed decisions concerning against antiseptic products based on their composition. The book contributes to reduce any unnecessary selection pressure towards emerging pathogens and to keep the powerful antiseptic agents for all those applications that have a clear benefit (e.g. reduction of healthcare-associated infection).

Long description:

Various antiseptic agents, such as chlorhexidine, are used for different applications, e.g. in healthcare, veterinary medicine, animal production and household products, including cosmetics. However, not all antiseptic agents provide significant health benefits, especially in some products used in human medicine (alcohol-based hand rubs, antimicrobial soaps). While some products (antimicrobial soaps, surface disinfectants, instrument disinfectants, wound antiseptics) may contain one or more biocidal agents with a comparable antimicrobial efficacy but large differences in their potential for microbial adaptation and tolerance. An increased bacterial resistance has been described for various antimicrobial agents, sometimes including a cross-resistance to antibiotics.

1. Chemical characterization.- 2. Types of application.- 2a. Approval by ECHA.- 2b. Approval by EPA.- 2c. Amounts per type of application (overall environmental impact).- 3. Spectrum of antimicrobial activity.- 3a. Bactericidal activity.- 3b. Fungicidal activity.- 3c. Mycobactericidal activity.- 3d. Virucidal activity.- 3e. Sporicidal activity.- 4. Natural resistances.- 5. Adaptation after exposure.- 5a. Per type of typical application.- 6. 7. Cross-resistance to other biocidal agents.- 8. Cross-resistances to antibiotics.- 9. Proposal for responsible use (antiseptic stewardship).