Actin-Binding Proteins and Disease
Series: Protein Reviews; 8;
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Estimated delivery time: In stock at the publisher, but not at Prospero's office. Delivery time approx. 3-5 weeks.
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Product details:
- Edition number 2008
- Publisher Springer New York
- Date of Publication 26 November 2007
- Number of Volumes 1 pieces, Book
- ISBN 9780387717470
- Binding Hardback
- No. of pages348 pages
- Size 235x155 mm
- Weight 740 g
- Language English
- Illustrations XIV, 348 p. 52 illus., 22 illus. in color. Illustrations, black & white 0
Categories
Long description:
Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility.
There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders.
This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders.
MoreTable of Contents:
Actin.- Actin: An Overview of Its Structure and Function.- Actin Genetic Diseases.- Actin-Binding Drugs: An Elegant Tool to Dissect Subcellular Processes in Endothelial and Cancer Cells.- Autoantigenicity of Actin.- Actin-Binding Proteins.- Overview: Actin-Binding Protein Function and Its Relation to Disease Pathology.- ADF/Cofilin, Actin Dynamics, and Disease.- Gelsolin and Disease.- Profilin.- The Roles of Thymosin ?4 in Cell Migration and Cell-to-Cell Signaling in Disease.- Actin-Binding Proteins.- Actin and Actin-Binding Proteins in Cancer Progression and Metastasis.- Diseases with Abnormal Actin and Actin-Binding Proteins in Leukocyte and Nonmuscle Cells.- The Role of PIP2 in Actin, Actin-Binding Proteins and Disease.- Intracellular Pathogens and the Actin Cytoskeleton.- Actin and Its Binding Proteins in Heart Failure.
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