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TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.

• Presents the perspectives of several life science research specialties on the topic
• Provides a comprehensive picture of the TRP field, from TRP channel dysfunction through TRP drug discovery and development to clinical trials and everyday medical practice
• Represents an updated and complete reference

"...a comprehensive, current overview of the TRP channel field, especially in the context of pathologies in which TRP channels could be involved, and consequently, their potential as targets for therapeutic intervention.... The book would best serve an audience with advanced degrees in biomedical research and drug discovery.... The editor is widely published on the subject of TRP channels and is a recognized expert in the field.... Includes excellent chapters on structural insights into TRP channel function gained from recent advances in the use of cryogenic EM, clear explanation of the biophysics behind the thermal regulation of several TRP channels, and what genomics has to say about the potential for TRP channels as therapeutic targets.... [It] is the most recent, and it contains useful information not available in the other books." ?Doody's Book Review Service, 2025, R. Kyle Palmer, PhD (Opertech Bio)

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Tartalomjegyzék:

1. A brief introduction to trp channel biology
2. The crystal structure of trp channels: implications for drug discovery
3. TRP channel dysfunction in hereditary diseases ("TRP channelopathies")
4. Altered trp channel expression in acquired disease
5. TRP gene polymorphism and disease risk
6. Targeting trpv1 channels for pain relief
7. Trpa1 antagonists for pain relief
8. TRP channels and migraine
9. Emerging pain targets: trpm and trpc channels
10. Trp channels in bladder disorders
11. TRP channels in respiratory diseases
12. TRP channels: emerging targets in covid and its complications
13. TRP channels and cerebrovascular diseases
14. Targeting TRP channels for relief from itch
15. TRP channels in dermatological disorders
16. TRP channels in hypertension
17. TRP channels in diabetes, obesity, and metabolic syndrome
18. TRP channels cardiovascular disease
19. TRP channels and digestive disease
20. TRP channels and cancer
21. TRP channels for anxiety relief and for improving mental health
22. TRP channels and neurodegenerative disorders
23. Mucolipidosis
24. TRP channels and renal disease
25. TRP channels and arthritis
26. TRP channels and thermoregulation: therapeutic opportunities

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