Rodent Models of Neurodegenerative Disease by Javadpour, Pegah; Ghasemi, Rasoul;

Rövid leírás:

With rising prevalence in aging populations worldwide, neurodegenerative disorders place burdens on patients, families, and healthcare systems. This volume, Rodent Models of Neurodegenerative Diseases, provides an in-depth examination of the strengths and limitations of rodent models in unraveling many aspects of neurodegeneration.

Hosszú leírás:

Rodent Models of Neurodegenerative Disease explores neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Lewy body disease, and prion disease which represent some of the most complex and devastating challenges in neuroscience. With rising prevalence in aging populations worldwide, these disorders place immense burdens on patients, families, and healthcare systems. This comprehensive volume, Rodent Models of Neurodegenerative Disease, provides an in-depth examination of the utility, strengths, and limitations of rodent models in unraveling the molecular, cellular, and behavioral aspects of neurodegeneration. Organized by disease, each chapter explores both genetic and non-genetic models, highlighting their relevance to human pathology, translational value, and contributions to therapeutic discovery.

Key features of this book include the following:

• Detailed coverage of rodent models for major neurodegenerative diseases


• Critical analysis of disease mechanisms, from protein aggregation and mitochondrial dysfunction to neuroinflammation and synaptic loss


• A dedicated chapter on behavioral assays, bridging molecular pathology with motor, cognitive and social outcomes


• Insights into the translational challenges of preclinical research and its role in shaping future therapies

With contributions from leading neuroscientists, this book serves as a valuable reference for researchers, graduate students, and professionals in neuroscience, neurology, pharmacology, and related fields. Whether for experimental design, model selection, or therapeutic evaluation, it provides an essential guide for advancing neurodegenerative disease research.

Tartalomjegyzék:

Chapter I Introduction to Animal Models in Neurodegenerative Research: Bridging the Gap Between Lab and Clinic Chapter 1 Rodent Models of Alzheimer’s Disease Chapter 2 Rodent Models of Parkinson’s Disease Chapter 3 Rodent Models of Amyotrophic Lateral Sclerosis Chapter 4 Rodent Models of Frontotemporal Dementia Chapter 5 Rodent Models of Lewy Body Disease Chapter 6 Rodent Models of Huntington’s Disease Chapter 7 Rodent Models of Prion Disease Chapter 8 Behavioral Assays in Rodent Models: Methods for Assessing Motor, Cognitive, and Social Phenotypes