Rodent Models of Neurodegenerative Disease by Javadpour, Pegah; Ghasemi, Rasoul;

Short description:

With rising prevalence in aging populations worldwide, neurodegenerative disorders place burdens on patients, families, and healthcare systems. This volume, Rodent Models of Neurodegenerative Diseases, provides an in-depth examination of the strengths and limitations of rodent models in unraveling many aspects of neurodegeneration.

Long description:

Rodent Models of Neurodegenerative Disease explores neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Lewy body disease, and prion disease which represent some of the most complex and devastating challenges in neuroscience. With rising prevalence in aging populations worldwide, these disorders place immense burdens on patients, families, and healthcare systems. This comprehensive volume, Rodent Models of Neurodegenerative Disease, provides an in-depth examination of the utility, strengths, and limitations of rodent models in unraveling the molecular, cellular, and behavioral aspects of neurodegeneration. Organized by disease, each chapter explores both genetic and non-genetic models, highlighting their relevance to human pathology, translational value, and contributions to therapeutic discovery.

• Detailed coverage of rodent models for major neurodegenerative diseases.

• Critical analysis of disease mechanisms, from protein aggregation and mitochondrial  dysfunction to neuroinflammation and synaptic loss.

• A dedicated chapter on behavioral assays, bridging molecular pathology with motor, cognitive, and social outcomes.

• Insights into the translational challenges of preclinical research and its role in shaping future therapies.

With contributions from leading neuroscientists, this book serves as a valuable reference for researchers, graduate students, and professionals in neuroscience, neurology, pharmacology, and related fields. Whether for experimental design, model selection, or therapeutic evaluation, it provides an essential guide for advancing neurodegenerative disease research.

Dr. Pegah Javadpour, PhD, is Assistant Professor of Medical Physiology at the Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Her research focuses on mitochondrial dysfunction, oxidative stress, and neuroinflammation in neurodegenerative disorders, particularly Parkinson’s and Alzheimer’s diseases. She has a special interest in mitochondria-targeted therapeutic strategies, including mitochondrial transplantation therapy (mitotherapy), as potential treatments for these conditions.

Dr. Rasoul Ghasemi, PhD, is Associate Professor of Medical Physiology in the Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. His research explores the neurophysiology of learning and memory, with emphasis on insulin signaling, hippocampal function, neuroinflammation, oxidative stress, and neuroprotection in neurodegenerative diseases. He has published extensively on the cellular and molecular mechanisms underlying brain resilience and pathology.

Table of Contents:

Chapter I Introduction to Animal Models in Neurodegenerative Research: Bridging the Gap Between Lab and Clinic Chapter 1 Rodent Models of Alzheimer’s Disease Chapter 2 Rodent Models of Parkinson’s Disease Chapter 3 Rodent Models of Amyotrophic Lateral Sclerosis Chapter 4 Rodent Models of Frontotemporal Dementia Chapter 5 Rodent Models of Lewy Body Disease Chapter 6 Rodent Models of Huntington’s Disease Chapter 7 Rodent Models of Prion Disease Chapter 8 Behavioral Assays in Rodent Models: Methods for Assessing Motor, Cognitive, and Social Phenotypes