Management of Early Parkinson's Disease by Pahwa, Rajesh; Lyons, Kelly;

Sorozatcím: Oxford American Pocket Notes;

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A termék adatai:

Kiadó OUP USA
Megjelenés dátuma 2010. február 4.

ISBN 9780195386493
Kötéstípus Spirálkötés
Terjedelem46 oldal
Méret 171x101x10 mm
Súly 55 g
Nyelv angol

Kategóriák

Klinikai orvostudomány és belgyógyászat általában Ideggyógyászat, neurológia

Hosszú leírás:

Parkinson's Disease (PD) is a progressive, neurodegenerative disorder with the cardinal symptons of bradykinesia, rigidity and tremor, as well as a postural inability in the later stages of the disease. It has been estimated that over 1,000,000 people in the United States are affected by PD with approximately 50,000-60,000 new cases diagnosed each year. The average age of PD onset is 60 years, although persons can onset much later and approximately 4-10% onset prior to the age of
40. The primary neurochemical change in PD is a loss of dopamine in the substantia niger, although it is increasingly recognized that additional neurotransmitters and brain areas are involved. The cause of PD is unknown, and there is currently no cure available.

The treatment of PD can be challenging and treatment of early PD can be complex with choice of initial therapy, as well as timing the initiation of therapy. Although there are currently no treatments approved to stop or slow the progression of PD, this is an area of active research, as it is estimated that approximately 60-80% of dopamine neurons are lost by the time of diagnosis. There are several symptomatic treatments available for all stages of PD, including monoamine oxidase type B
(MAO-B) inhibitors, dopamine agonists, levodopa, and less commonly, anticholinergics and amantadine. The treatment regimen in the early stage needs to be individualized based on the disease characteristics and life situation of each patient. The goal of therapy in early PD is to identify a treatment
strategy to control the parkinsonian symptons, such as motor fluctuations and dyskinesia, without causing adverse events.

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Tartalomjegyzék:

Contents
Contributors
Introduction
Epidemiology
Diagnostic Criteria
Common Differential Diagnoses
Common Early Symptons of PD
Assessments
Neuroprotection
Early Symptomatic Treatment Options
Dosing Information
Considerations for Initiation of Treatment
Early Symptomatic Treatment Options
Comparison of Common Dopaminergic Adverse Events
Dopamine Agonists - Safety Concerns
MAO-B Inhibitors - Safety Concerns
Evidence-Based Guidelines for the Treatment of Early Parkinson's Disease
Early PD Management: Proposed Treatment Strategy for Newly Diagnosed Patients
Non-Pharmacologic Treatment
Internet Resources
Rating Scales and Other Assessment Guidelines
References