Tumour Angiogenesis
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Product details:
- Publisher OUP Oxford
- Date of Publication 3 July 1997
- ISBN 9780198549376
- Binding Hardback
- No. of pages396 pages
- Size 255x198x28 mm
- Weight 1163 g
- Language English
- Illustrations 8 pp colour plates, halftones, line figures, tables 0
Categories
Short description:
It is now widely recognised that the growth of solid tumours is angiogenesis dependent. The inhibition of tumour angiogenesis offers a novel anti-cancer therapeutic strategy. In this first book to be devoted solely to tumour angiogenesis each chapter is written by leading world experts and the twenty seven chapters taken together cover all aspects of the field.
MoreLong description:
Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases, extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth
factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforming growth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are
addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and the therapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.
'...a timely book about an area that is rapidly gaining in popularity...this contribution will be most useful for the researchers in the field, in particular for scientists new to angiogenesis who will benefit from this extensive and thorough introduction. The book will also function well as a dictionary for people working in related areas...this is an extensive, well written and comprehensive book.'
Table of Contents:
Introduction
In Vivo Models of Angiogenesis
Mechanistic Studies of Tumour Angiogenesis
Prognostic and Predictive Value of Intra-tumoral Microvessel Density in Human Solid Tumours
Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection & Treatment
Microregional Tumour Blood Flow: Heterogeneity & Therapeutic Significance
Mechanisms of Stress-Induced Angiogenesis in Tumours
The role of Macrophages in Tumour Angiogenesis
Oncogenes and Tumour Suppressor Genes in the Regulation of Angiogenesis
The role of cytokines in angiogenesis
The Role of Proteases in Angiogenesis
Involvement of the Extracellular Matrix, Heparan Sulfate Proteoglycans and Heparan Sulfate Degrading Enzymes in Angiogenesis and Metastasis
The Role of Collagens and Proteoglycans in Tumour Angiogenesis
The Physiological Importance and Therapeutic Potential of Nitric Oxide in the Tumour-associated Vasculature
Vascular Derived Growth Factors: Potential Role in the Development of the Tumour Vasculature
The Role of Vascular Endothelial Growth Factor in the Regulation of Blood Vessel Growth
The Role of Fibroblast Growth Factors in Tumour Progression and Angiogenesis
The Biphasic Effects of Transforming Growth Factor in Angiogenesis
Thymidine phosphorylase/platelet-derived endothelial cell growth factor an angiogenc enzyme
Tumor Necrosis Factor and Angiogenesis
Pleiotrophin and Related Molecules
The Involvement of prostanoids in angiogenesis
The Inhibition of tumour angiogenesis
Endothelial Cells Transformed by Polyomavirus Middle-T Oncogene: A Model for Haemangiomas and Other Vascular Tumours
Development of the Embryonic Vascular System
Targeting the Tumour Endothelium Using Specific Antibodies
Vascular Targeting of anti-cancer gene therapy
