Product details:
ISBN13: | 9780367387181 |
ISBN10: | 0367387182 |
Binding: | Paperback |
No. of pages: | 224 pages |
Size: | 234x156 mm |
Weight: | 408 g |
Language: | English |
143 |
Category:
Natural sciences in general, history of science, philosophy of science
Biology in general
Histology
Immunology, allergology
Natural sciences in general, history of science, philosophy of science (charity campaign)
Biology in general (charity campaign)
Histology (charity campaign)
Immunology, allergology (charity campaign)
Signaling by Toll-Like Receptors
Edition number: 1
Publisher: CRC Press
Date of Publication: 7 October 2019
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Short description:
The recent discovery of an ancient family of toll-like receptors (TLRs) in the immune system has substantially enhanced the potential for a variety of therapies, for both failing immune systems, which leaves the body open to infection or over-active ones, which can lead to chronic inflammation. Signaling by Toll-Like Receptors provides a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors, as well as the high promise for uncovering effective pharmaceutical targets.
Long description:
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.
Table of Contents:
Assessing the Response of Cells to TLR Stimulation. TLR Ligands in Experimental Settings: Their Purity and Specificity. Analysis of TLR Expression, Regulation, and Signaling. Intracellular Trafficking of Toll-Like Receptors. The Role of Small RhoGTPases in TLR Signaling. Use of Engineered &&&946;-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors. Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling. Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling. Role of Toll-Like Receptor Signaling in Central Nervous System Infections. The Influence of Injury on Toll-Like Receptor Responses. Index.