Physiological Mapping of the Cerebral Cortex in Neuropathology
Mitochondrial Function, CBF, Ionic Homeostasis and Electrical Activities
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Product details:
- Publisher Springer Nature Switzerland
- Date of Publication 21 May 2026
- ISBN 9783032130181
- Binding Hardback
- No. of pages572 pages
- Size 235x155 mm
- Language English
- Illustrations XX, 572 p. 97 illus., 74 illus. in color. 700
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Long description:
This book covers a new concept and unique approach named “Physiological Mappingâ€- of the cerebral cortex in the ratâ€TMs brain. The unique parameter that is used in the authorsâ€TM studies is the monitoring, in vivo and in real time, of the mitochondrial NADH redox state. In addition, the monitoring of cerebral blood flow, tissue oxygen level, extracellular potassium ion and DC potential as well as ECoG is reported.
The main pathological event that was studied was cerebral ischemia that mimic the stroke developed in patients. Different models of ischemia were investigated by using the developed concept of “Physiological Mappingâ€-. A unique chapter in the book describes and discuss an event named “Metabolic Oscillationsâ€- that developed mainly in the ischemic brain. Also the role of nitric oxide in various pathophysiological conditions such as ischemia, hypoxia, and hypercapnia are discussed.
In addition to stroke, the book describes in detail the physiological mapping of the cerebral cortex in the brain exposed to epilepsy. The interaction between the epilepsy developed in the brain and partial ischemia, nitric oxide, hyperoxia and anesthesia is presented in detail.
The last chapter of the book describes the effects of an animalâ€TMs age on the responses to ischemia. Also the effects of traumatic brain injury in the rat is discussed.
This is an ideal book for neurologists as well as clinicians in the field of neurosurgery and anesthesiology.
MoreTable of Contents:
Chapter 1: Historical Background and Introduction.- Chapter 2: Brain Biochemical and Physiological Activities-In Vivo Markers of Brain Pathology.- Chapter 3: Real-Time Brain Responses to Various Models of Ischemia.- Chapter 4: Oscillations of Brain Mitochondrial NADH and CBF under Ischemia.- Chapter 5: Mitochondrial Contribution to the Pathophysiology of Cerebral Ischemia.- Chapter 6: The Involvement of Nitric Oxide (NO) in the Regulation of Brain Physiological Activities.- Chapter 7: Responses to Epileptic Activity Developed Under Various Pathophysiological.- Chapter 8: The Effects of Aging and TBI on Brain Physiological Functions.- Chapter 9: General Discussion and Conclusions.
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