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    Nonlinear Models for Medical Statistics

    Nonlinear Models for Medical Statistics by Lindsey, J.K.;

    Series: Oxford Statistical Science Series; 26;

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      • Publisher's listprice GBP 145.00
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    Product details:

    • Edition number 2 Rev ed
    • Publisher OUP Oxford
    • Date of Publication 19 July 2001

    • ISBN 9780198508120
    • Binding Hardback
    • No. of pages292 pages
    • Size 242x161x21 mm
    • Weight 556 g
    • Language English
    • Illustrations numerous tables and figures
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    Short description:

    This book provides an introduction to the use of nonlinear modelling in medical statistics, including worked through examples in most areas where such techniques are used. It is suitable for both professional and academic statisticians working in medical research. The data and computer code for the examples will be available on the authors web site.

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    Long description:

    This text provides an introduction to the use of nonlinear models in medical statistics, It is a practical text rather than a theoretical one and assumes a basic knowledge in statistical modelling and of generalized linear models.

    The book first provides a general introduction to nonlinear models, comparing them to generalized linear models. It describes data handling and formula definition and summarises the principal types of nonlinear regression formulae. there is an emphasis on techniques for non-normal data.

    Following chapters provide detailed examples of applications in various areas of medicine, epidemiology, clinical trials, quality of life, pharmokinetics, pharmacodynamics, assays and formulations, and molecular genetics.

    The book concludes with appendicies describing data handling and model formulae in more detail, and given ways of modelling dependencies in repeated measurements, and data for the exercises.

    This book is a great introduction to the topic of nonlinear models and is probably the only book that deals with some of the concepts. Lindsey's writing style makes easy reading and very useful reference ... this book is a must for those working in early phase clinical trials, particularly in the discipline of pharmacokinetics and pharmacodynamics.

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    Table of Contents:

    Preface
    Basic concepts
    Practical aspects
    Families of nonlinear regression functions
    Epidemiology
    Clinical trials
    Quality of life
    Pharmacokinetics
    Pharmacodynamics
    Assays and formulations
    Molecular genetics
    Data and model examples from R
    Stochastic dependence structures
    Data tables for the exercises
    Bibliography
    Author index
    Subject index

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