New Anticancer Drugs by Carter, S.K.; Sakurai, Y.;

Table of Contents:

of U.S.-Japan Joint Meeting on Phase I and II Clinical Trials.- The New NCI Screen and Its Implications for Clinical Evaluation.- The National Cancer Institute’s Natural Products Antineoplastic Development Program.- Methodology of Phase I Study in Japan.- Methodology of Phase II Clinical Trial in Cancer.- Phase II Study of Antineoplastic Agents in Japan.- Clinical Strategy for Evaluation of Anthracycline Analogues.- Preliminary Clinical Study of Aclacinomycin A.- Preclinical and Clinical Studies on Chlorozotocin, a New Nitrosourea with Decreased Bone Marrow Toxicity.- Continuation of Phase II Study of 1-(4-Amino-2-Methylpyrimidine-5-yl)-Methyl-3-(2-Chloroethyl)-3-Nitrosourea Hydrochloride (ACNU).- Review of Experimental Studies on Nitrosourea Derivates in Japan.- The Clinical Evaluation of Analogues, IV. Nitrosoureas.- Review of a New Antimetabolic Agent, 1-Hexylcarbamoyl-5-Fluorouracil (HCFU).- Review of a New Antimetabolic Agent, 1,1-Bis(Tetrahydro-2-Furanyl)-5-Fluoro-2,4-Pyrimidinedione (FD-1).- Effect and Mode of Action of N4-Behenoyl-?-D-Arabinofuranosylcytosine.- Strategy for Evaluation of a New Antitumor Agent in the Treatment of Breast Cancer.- Current Status of Breast Cancer Chemotherapy in Japan.- Present Status of Lung Cancer Chemotherapy in Japan.- Clinical Strategies in the Chemotherapy of Gastrointestinal Cancer.- Clinical Evaluation Strategy in Specific Disease Types — Clinical Study of Gastrointestinal Cancer Chemotherapy in One Institute of Japan.- A Review of Therapeutic Strategies for Phase I-II Trials in Genitourinary Cancer.- Recent Results of Using a Sequential Combination of Bleomycin and Mitomycin C in the Treatment of Metastatic Cervical Cancer.- Pharmacologic and Clinical Studies of N4-Behenoyl-1-Beta-D-Arabinofuranosylcytosine.