Navigating Tuberculosis
Insights into Host-Pathogen Protein Interactions
Series: Foundations and Frontiers in Enzymology;
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63 663 Ft
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Product details:
- Publisher Elsevier Science
- Date of Publication 19 August 2026
- ISBN 9780443277351
- Binding Paperback
- No. of pages325 pages
- Size 235x191 mm
- Weight 450 g
- Language English 0
Categories
Long description:
Navigating Tuberculosis: Insights into Host-Pathogen Protein Interactions, the latest release in the Foundations and Frontiers in Enzymology series, explores the interactions between host proteins and the tuberculosis pathogen, Mycobacterium tuberculosis (M. tb), emphasizing their roles in virulence and pathogenesis. The book delves into mechanistic insights, focusing on their roles in modulating innate and adaptive immunity and understanding TB pathomechanisms by elucidating the interplay between host defenses and M. tb infection. It provides a foundation for developing targeted mitigation strategies and discusses key regulatory pathways and protein factors involved in host-pathogen interactions, informing the design and implementation of innovative approaches to combat TB.
This comprehensive volume aims to advance knowledge and strategies to combat tuberculosis, aligning with the World Health Organization's goal of eradicating TB by 2035 by addressing the need for up-to-date information on host-pathogen interactions in tuberculosis and incorporating the latest research findings and advancements. It highlights emerging therapeutic targets among host and TB pathogen proteins and integrates multidisciplinary approaches from microbiology, immunology, and molecular biology, offering a holistic perspective on TB pathophysiology. Researchers will find detailed discussions on key host proteins involved in tuberculosis pathogenesis, the molecular tactics employed by M. tb to subvert host defenses, and host-mediated inhibition strategies targeting M. tb.
Table of Contents:
1. Mechanisms of Mycobacterium tuberculosis Virulence: The esx1 Locus and Host Countermeasures
2. Host Adaptation Strategies of Mycobacterium tuberculosis: A Molecular Perspective
3. Unravelling M. tuberculosis Manipulation of Host Immunity: Insights from Functional Genomics and Proteomics
4. Macrophages: Frontline Warriors Against Mycobacterium tuberculosis Invasion
5. Unravelling Mycobacterium tuberculosis Pathogenesis: Insights into PE/PPE Proteins from a Molecular Viewpoint
6. Host-Pathogen Dynamics in Mycobacterium tuberculosis: The Impact of PE/PPE Proteins on Innate and Adaptive Immunity
7. PE/PPE Proteins in Mycobacterium tuberculosis: Key Regulators of Apoptosis and Pathogenic Outcomes
8. Autophagy and Mycobacterium tuberculosis: Host Defense Mechanisms Versus Pathogen Evasion
9. Mechanisms of Phagosomal Damage Detection and Response to Mycobacterium tuberculosis: Repair, Autophagy, and Biogenesis
10. Programmed Cell Death During Mycobacterium tuberculosis Infection: The Roles of Pyroptosis and Necroptosis in Host Defense
11. Metabolic Repurposing in Mycobacterium-Infected Macrophages: A Strategy for Enhanced Virulence and Survival
12. Type I Interferons in Tuberculosis: Friend or Foe?
13. Type II Interferon in Tuberculosis: Orchestrating Infection Outcome through Mechanistic Insights
14. Cell Envelope Dynamics in Mycobacterium tuberculosis: Implications for Tuberculosis Pathogenesis and Host-Pathogen Interaction
15. Combatting Tuberculosis Drug Resistance: Effective Strategies for Overcoming Challenges
16. Beyond Treatment: Strategies for Mitigating Long-Term Morbidity and Mortality in Tuberculosis Survivors
