Metchnikoff and the Origins of Immunology
From Metaphor to Theory
Series: Monographs on the History and Philosophy of Biology;
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106 299 Ft
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Product details:
- Publisher OUP USA
- Date of Publication 31 October 1991
- ISBN 9780195064476
- Binding Hardback
- No. of pages280 pages
- Size 155x237x23 mm
- Weight 581 g
- Language English 0
Categories
Short description:
This fascinating intellectual history is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory that phagocytic cells actively defend the host body against pathogens and diseased cells.
In this scientific biography, Tauber and Chernyak explore Metchnikoff's development as an embryologist, showing how it prepared him to propose his theory of host-pathogen interaction. They discuss the profound impact of Darwin's theory of evolution on his progress, and the influence of 19th century debates on vitalism, teleology, and mechanism. As a case study of scientific discovery, this work offers lucid insight into the process of creative science and its dependence on cultural and philosophic sources.
Long description:
This fascinating intellectual history is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory that phagocytic cells actively defend the host body against pathogens and diseased cells.
In this scientific biography, Tauber and Chernyak explore Metchnikoff's development as an embryologist, showing how it prepared him to propose his theory of host-pathogen interaction. They discuss the profound impact of Darwin's theory of evolution on his progress, and the influence of 19th century debates on vitalism, teleology, and mechanism. As a case study of scientific discovery, this work offers lucid insight into the process of creative science and its dependence on cultural and philosophic sources.
Tauber and Chernyak have produced a scholarly and detailed study of the origins of the deep and long controversy between the cellular and humoral basis of immunity.
Table of Contents:
Foreword; Preface; Introduction; Metchnikoff's early embryology; Metchnikoff's embryological studies after 1872; The problem of evolution in Metchnikoff's works; Metchnikoff's emerging concept of inflammation; The phagocytosis theory and its reception; The phagocyte eclipsed; Epilogue: From metaphor to theory; Notes and references; Appendix A: Morphologists vs. Darwinians, the modern debate; Appendix B: Current views of phagocyte function.
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