Ion Channels
From Structure to Function
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Product details:
- Publisher OUP Oxford
- Date of Publication 17 September 2009
- ISBN 9780199296750
- Binding Hardback
- No. of pages576 pages
- Size 284x227x28 mm
- Weight 1733 g
- Language English
- Illustrations 62 halftone figures, 8pp colour plates 0
Categories
Short description:
Ion channels are involved in everyday physiological functions that enable us to live a full and varied life. Aimed at both ion channel specialists and non-specialists, this book reviews the basic principles of ion channel function and provides a detailed review of the physiological and pharmacological aspects of individual ion channel sub-families.
MoreLong description:
Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent processes is often involved, either as the cause or effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases.
This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts:
Part one - an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterisation through to the deployment of high throughput approaches for identifying novel ion channel ligands.
Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter therein focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily.
Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the physiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
Table of Contents:
Introduction
Introduction to Ion Channel Structure and Function
Voltage Gated Ion Channels
Voltage-Gated K+ channels
Kv1-Kv6 \ Kv8-Kv9 family
Kv7 family
Kv10-Kv12 families
K2P families
Voltage-Gated Ca2+ Channels
Voltage-Gated Na+ Channels
Voltage-Gated Chloride Channels
Hyperpolarization-Activated Channels
Extracellular Ligand-Gated Ion Channels
Cys Loop Receptors
Nicotinic Acetylcholine Receptors
5-HT3 receptors
Glycine Receptors
GABAA receptors
Glutamate Receptors
AMPA Receptors
Kainate Receptors
NMDA Receptors
ATP Receptors
P2X Receptors
Others
Acid Sensing Ion Channels (ASICs)
Epithelial Sodium Channels
Intracellular Ligand-Gated Ion Channels
Chloride Channels Activated by Intracellular Ligands
Cyclic Nucleotide-Gated Cation Channels
KCa1- KCa5 Families
KIR family
KIR1,2,4,5,7 families
KIR3 family
KIR6 (KATP) family
Ryanodine Receptors
IP3 receptor
Polymodal Gated Ion Channels
Transient Receptor Potential Channels
Connexins - Gap Junctions
