Introductory Review on Sirtuins in Biology, Aging, and Disease
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Product details:
- Publisher Elsevier Science
- Date of Publication 25 April 2018
- ISBN 9780128134993
- Binding Paperback
- No. of pages220 pages
- Size 234x190 mm
- Weight 480 g
- Language English 0
Categories
Long description:
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.
MoreTable of Contents:
1. Early Sirtuin Research 1991-2000
2. Regulation of sirtuins by systemic NAD+ biosynthesis
3. NAD modulation - biology and therapy
4. The enzymatic activity of sirtuins
5. Molecular mechanisms of Sirtuin activation and inhibition
6. Pharmacological approaches for modulating sirtuins
7. Mitochondrial Sirtuins
8. Biological Roles and Activities for Mitochondrial Sirtuins
9. The multitasking roles of the mammalian deacetylase SIRT6
10. Chromatin and nuclear signaling: SIRT7 function in the nucleolus and beyond
11. Sirtiuns and Carcinogenesis
12. Roles for sirtuins in cardiovascular biology
13. Sirtuins in Brain Biology and Disease
