Immunity and Inflammation in Health and Disease by Chatterjee, Shampa; Jungraithmayr, Wolfgang; Bagchi, Debasis;

Long description:

Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health.

Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions.

This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here.

Table of Contents:

Section I: Innate and Adaptive Immune Systems: Components and Regulation
1. Innate and Adaptive Immunity: Barriers and Receptor Based Recognition
2. Innate Immunity at Birth: Implications for Inflammation and Infection in Newborns
3. Redox Signaling and Onset of the Inflammatory Cascade

Section II: Reactive Oxygen Species, Oxidative Stress and Immune Cell Activation
4. Reactive Oxygen Species, Oxidative Damage and Cell Death
5. Mitochondrial ROS and T Cell Activation
6. Oxidants and Inflammation: Endothelial Targeting Of Antioxidants to Combat Disease
7. Oxidative Signaling In Chronic Obstructive Airway Diseases

Section III: Inflammatory Systems: Mechanistic Pathways Of Stimulation and Suppression
8. Immune Responses in the Upper Respiratory Tract in Health and Disease
9. The Biological Role of NADPH Oxidases in Pulmonary Ischemia-Reperfusion Injury in Pulmonary Inflammation
10. Receptor Blockade of CD26/DPP4 as a Therapeutic Strategy Against I/R Injury and Lymphocytic Inflammation And Its Clinical Implications
11. DPPIV/CD26 as A Target in Anti-Inflammatory Therapy
12. Redox Sensitive Transcription via Nrf2-Keap1 in Suppression of Inflammation

Section IV: Immunity and Inflammation: Common Threads Of Multifactorial Diseases
13. Monogenic Defects of Toll-Loke receptor Signaling and Primary Immunodeficiency
14. PPAthogen - and Microbial- Associated Molecular Patterns (PAMPs/MAMPs) in the Innate Immune Response in Crohn's Disease
15. Inflammation and Calcification in the Vascular Tree; Insights into Atherosclerosis
16. From Inflammation to Cancer: Opportunites for Chemoprevention via Dietary Intervention
17. Inflammation in Bullous Pemphigoid, a Skin Auto-Immune Disease
18. Inflammation in Systemic Immune Diseases: Role of TLR9 Signaling and the Resultant Oxidative Stress in Pathology of Lupus

Section V: Nutraceuticals in Boosting Immune Support and as Therapeutics for Inflammatory Diseases
19. Anti-inflammatory and Anti-microbial Properties of Achillea millefolium in Acne Treatment
20.ï¿1⁄2Lactobacillus Gasseri Potentiates Immune Response Against Influenza Virus Infection
21. Micronutrients in Skin Immunity and Associated Diseases
22. Mycobiome and Gut Inflammation: Implications in Inflammatory Bowel Disease
23. Flavonoids in Treating Psoriasis
24. Probiotics and Anti-Inflammatory Processes in HIV Infected: From Benchside Research to Bedside
25. Chronic Inflammation in Asthma: Anti-Malarial Drug Artesunate as a Therapeutic Agent
26. Nutrition as a Tool to Reverse Immunosenescence?

Section VI: New Perspectives and Future Directions
27. Therapeutic Interventions to Block Oxidative Stress-Associated Pathologies
28. Phytochemicalsï¿1⁄2as Anti-Inflammatory Nutraceuticalsï¿1⁄2and Phytophamaceuticals
29. Fermented Milk in Protection Against Inflammatory Mechanisms In Obesity
30. Prebiotics and Probiotics in Altering Microbiota: Implications in Colorectal Cancer
31. Naturopathy and Lifestyle Interventions in Boosting Immune Responses in HIV Positive Population
32. Eating Habits and Fighting Disease: Nutraceuticals and Functional Foods at the Intersection of Immune Health and Inflammatory Responses