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  • False Hope: Bone Marrow Transplantation for Breast Cancer

    False Hope by Rettig, Richard A.; Jacobson, Peter D.; Farquhar, Cynthia M.;

    Bone Marrow Transplantation for Breast Cancer

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      • Publisher's listprice GBP 51.00
      • The price is estimated because at the time of ordering we do not know what conversion rates will apply to HUF / product currency when the book arrives. In case HUF is weaker, the price increases slightly, in case HUF is stronger, the price goes lower slightly.

        24 365 Ft (23 205 Ft + 5% VAT)
      • Discount 10% (cc. 2 437 Ft off)
      • Discounted price 21 929 Ft (20 885 Ft + 5% VAT)

    24 365 Ft

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    Product details:

    • Publisher OUP USA
    • Date of Publication 1 March 2007

    • ISBN 9780195187762
    • Binding Hardback
    • No. of pages368 pages
    • Size 166x240x24 mm
    • Weight 685 g
    • Language English
    • Illustrations 5 line illustrations
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    Short description:

    In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we evaluate other medical procedures, especially life-saving ones.

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    Long description:

    In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we evaluate other medical procedures, especially life-saving ones.

    It details how the factors that drove clinical use - patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates - converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyses the failure of the technology assessments and randomised clinical trials that evaluated the procedure and the ramifications of this flawed system on healthcare today.

    Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.

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    Table of Contents:

    Part I: Initial Conditions
    Breast Cancer Patients and the Emergence of a Treatment
    Jumping the Gun
    Part II: Drivers of Clinical Use
    Court Trials
    Litigation Strategies
    Entrepreneurial Oncology
    Government Mandates
    Part III: The Struggle of Evidence-Based Medicine
    Technology Assessments
    Clinical Trials
    Dénoument
    Part IV: The Significance of the Story
    Values in Conflict

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