Endotoxin in Critical Illness by Kellum, John; Foster, Debra;

Long description:

Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.

• Offers a comprehensive and in-depth understanding of endotoxin in critical illness, covering historical perspectives, molecular intricacies, physiological basis of disease, and evolutionary aspects
• Emphasizes the clinical relevance of endotoxin in critical illness, septic shock, trauma, and diseases like COVID-19 and provides comprehensive insight to the most malignant form of endotoxemia, endotoxic septic shock (ESS)
• Reflects on the current state of knowledge and potential future directions, including personalized medicine approaches, acknowledging the evolving nature of the field and inspiring continued research and innovation

Table of Contents:

1. Sepsis and Endotoxin: a brief history
2. Anti-endotoxin therapies
3. Endotoxemia in COVID-19
4. Endotoxin signally -the TLR4 pathway and Alternates
5. Endotoxin Pathophysiology
6. Origins of Human Sensitivity to Endotoxin and Implications for Sepsis Therapeutic Development
7. Endotoxin and the Gut Microbiome
8. Quantifying endotoxin in the blood of humans; a personal journey toward development of the Endotoxin Activity Assay
9. Endotoxic septic shock
10. Endotoxin in Trauma
11. Therapeutic rationale for endotoxin removal with polymyxin B immobilized fiber column hemoperfusion (PMX-HP) for endotoxemic septic shock
12. Clinical Experience with PMX Cartridge in Sepsis and Septic Shock Management
13. Precision medicine for sepsis. A dream or a reality?