Controlled Drug Delivery of Hydrophobic Drug
Development and Evaluation of Oral Controlled Drug Delivery of BCS Class-II Drug Glipizide
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Product details:
- Publisher LAP Lambert Academic Publishing
- Date of Publication 1 January 2020
- ISBN 9786202518062
- Binding Paperback
- No. of pages96 pages
- Size 220x150 mm
- Language English 25
Categories
Long description:
Glipizide, an oral hypoglycemic agent, is one of the most commonly prescribed drugs for the treatment of patients with type II diabetes mellitus. It is practically water-insoluble, thus it belongs to class-II of Biopharmaceutical Classification System (BCS). Glipizide has a relatively short elimination half-life (2-4 h), thereby requiring twice daily dosing in large number of patients, which often leads to non-compliance. Thus, there is a strong clinical need and market potential for a dosage form that will deliver glipizide in a controlled manner to a patient needing this therapy, thereby resulting in a better patient compliance. The aim of present investigation was to enhance the solubility by using beta-cyclodextrin binary complexation and impart a controlled release in a single formulation in order to reduce dosing frequency.
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