Product details:

ISBN13:9781032310770
ISBN10:1032310774
Binding:Paperback
No. of pages:214 pages
Size:254x178 mm
Language:English
Illustrations: 27 Illustrations, color; 9 Halftones, color; 18 Line drawings, color; 3 Tables, black & white
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Category:

Cancer through the Lens of Evolution and Ecology

 
Edition number: 1
Publisher: CRC Press
Date of Publication:
 
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Short description:

Cancer cells exist in an ever-changing ?ecology? and are subject to evolutionary pressures just like any species in nature. The book is resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms.

Long description:

Cancer cells exist in an ever-changing ?ecology? and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms.


Key Features



  • Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated.

  • Offers insights from leading scholars in cancer biology, ecology and evolutionary biology.

  • Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment.

  • Integrates basic and applied sciences of oncology and evolutionary biology.

Table of Contents:

Foreword


Randolph Nesse


Chapter 1:  A species within a species


Jason A. Somarelli and Norman A. Johnson


Chapter 2: Therapy As a Driver of Evolutionary Selection


Dana Ataya, Joel S. Brown and Robert A. Gatenby


Chapter 3:  The Genetic Hitchhiker?s Guide to Tumor Evolution


Rohini Janivara and Joseph Lachance


Chapter 4: Multicellularity, phenotypic heterogeneity, and cancer


Christopher Helenek, Jason A. Somarelli, and Gábor Balázsi


Chapter 5: Feedback loops in gene regulatory networks and cell-cell communication networks: drivers of cancer cell plasticity


Yeshwanth Mahesh,  Subbalakshmi Ayalur Raghu, Mohit Kumar Jolly


Chapter 6: Polygenic Evolution of Germline Variants in Cancer


Ujani Hazra and Joseph Lachance


Chapter 7: Two-phased cancer evolution: the pattern and scale of genomic and nongenomic landscapes


Andrzej Kasperski and Henry H. Heng


Chapter 8: Evolutionary and ecological perspective on the multiple states of T cell exhaustion


Irina Kareva and Joel S. Brown


Chapter 9: Landscape Genetics for Cancer Biology


Erin L. Landguth and Norman A. Johnson


Chapter 10: Tumor Island Biogeography: Theory and Clinical Applications


Antonia Chroni


Chapter 11: Cancer and the Evolutionary Ecology of Invasions


Joel S. Brown, Sarah A. Amend and Kenneth J. Pienta


 Chapter 12: Unifying Theories in Comparative Oncology 


 Zachary T. Compton


 Chapter 13: From Evolutionary Biology to Bedside and Beyond: A View of Comparative Oncology Throughout the Translational Pipeline


Veronica Colmenares, William C. Eward, Laurie A. Graves


 Chapter 14: What do we gain from viewing cancer through an eco-evo lens?


Jason A. Somarelli and Norman A. Johnson