Cancer biotherapy
An introductory guide
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Product details:
- Publisher OUP Oxford
- Date of Publication 4 May 2006
- ISBN 9780198566311
- Binding Paperback
- No. of pages336 pages
- Size 233x156x19 mm
- Weight 516 g
- Language English
- Illustrations Numerous tables and line drawings 0
Categories
Short description:
Recent advances in biology and immunology have led to major developments in cancer therapies. Biotherapy, based on stimulating the immune system to attack cancer cells, is currently entering clinical practice. This book combines discussion of the underlying principles with strong clinical focus, highlighting clinical relevance and treatment issues.
MoreLong description:
Recent advances in biology and immunology have opened up new horizons in both our understanding of cancer as a disease, and the potential for cancer therapy. These major developments mean that chemotherapy, radiotherapy and surgery are no longer the only options. Biotherapy, or biological therapy, is now regarded as the fourth treatment modality for patients with cancer. It utilises the great increase in our knowledge of molecular biology, cell biology and immunology to achieve tumour control.
New biological agents are currently being used to treat cancer, such as monoclonal antibodies and vaccine therapies to stimulate the body's immune system to attack cancer cells. Biotherapy may be targeted to act specifically on cancer cells. Drugs such as monoclonal antibodies can be designed to recognize and find a particular type of cancer cell, attach itself to them, and destroy them. Naturally occuring biological molecules such as cytokines are also used, and the manipulation of normal biological mechanisms to control or inhibit tumour growth is another key feature of biotherapy.
Edited by a team with perspectives in pharmacology, oncology and nursing, and with contributions from experts in the various areas of biotherapy, this book serves as an introduction to the subject. It includes the principles behind biological therapy, with discussion of the impact on the future of the fight against cancer. It has a strong clinical focus, describing the relevant biology and immunology while highlighting clinical relevance and treatment issues.
The editors of this new book...provide a good introductory guide to a whole range of biological interventions. The authors do make the very important point that 'individualised' treatment is going to be the order of the day. All cancer are different, we have to find out how different they are with ever-improving laboratory testing, and we have to tailor treatment to suit each cancer's unique profile and bring them back under control biologically.
Table of Contents:
Introduction
An introduction to the cell biology of cancer
An introduction to the immune system and cancer
The clinical development of biologic therapies
Kinase inhibitors
The RAS pathway - a target for anticancer therapy
The development of cell cycle active agents for cancer therapy
Therapeutic monoclonal antibodies
Antibody Directed Enzyme Prodrug Therapy (ADEPT)
Cytokines
Inhibitors of invasion and angiogenesis
Proteins, peptides and DNA vaccines for cancer
Cell based immunotherapy
Gene therapy for cancer - approaches and ethical considerations
Individualising cancer therapy
Glossary
