Atherosclerosis
Gene Expression, Cell Interactions, and Oxidation
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Product details:
- Publisher OUP Oxford
- Date of Publication 9 November 2000
- Number of Volumes laminated boards
- ISBN 9780198506379
- Binding Hardback
- No. of pages464 pages
- Size 241x163x28 mm
- Weight 803 g
- Language English
- Illustrations line figures and tables 0
Categories
Short description:
Atheroslcerosis is the main cause of heart and blood vessel disease. This book reviews the underlying causes of atherosclerosis and points to future innovations in imaging, diagnosing, preventing, and reversing heart disease.
MoreLong description:
This book provides a critical review of the oxidative theory of atherosclerosis as well as highlighting new trends in research from basic to clinical, academic to commercial. The contributions of diabetes, vascular dysfunction, blood coagulation, plaque rupture, oxidative stress, lymphocytes, macrophages, growth factors, cytokines, and oxysterols to atherogenesis are all discussed, as are the roles of smooth muscle and endothelial cells. As well as a summary of the
current methods of diagnosis and the future prospect of using biochemical markers from plasma is also discussed. There is a critical look at gene therapy and other future therapeutic strategies based on the molecular and cellular causes of atherosclerosis. Each chapter is written by two or more
authors from different laboratories to ensure a balanced approach. It will be invaluable to all biomedical researchers with a specialist or passing interest in atherosclerosis research.
" ... this book will be of greatest value to investigators involved in cardiovasular research." Nature Cell Biology
Table of Contents:
The morphology and natural history of atherosclerosis; Diabetes and atherosclerosis; Antioxidant intervention studies in small animals; Antioxidant intervention studies in humans; Vascular dysfunction and its contribution to atherosclerosis; Gene therapy for vascular diseases: closer to delivering the goods; The endothelial cell in atherosclerosis; Oxidative stress and platelet formation in atherosclerosis; Macrophage lipid metabolism and atherosclerosis; Smooth muscle
cells and the connective tissue matrix of the initima; Lymphocytes in atherogenesis; Growth factors and cytokines in atherogenesis; Lipoprotein influx and efflux in the atherosclerotic intima; Inhibition of the cytokine-induced expression of endothelial cell adhesion molecules by high density
lipoproteins; Protein oxidation in atherogenesis; Anti-oxidants and co-antioxidation in lipoproteins and the intima; Oxysterols in atherogenesis;
Intracellular effects of cell surface-localized initiation of blood coagulation; Plaque rupture and its consequences; Diagnosis and thera
