Viral Hemorrhagic Fevers and Other Emerging Infections, Part B by Buchmeier, Michael; Peters, Clarence J;

Hosszú leírás:

Viral hemorrhagic fevers (VHFs) are a group of illnesses that are caused by several distinct families of viruses. While some types of hemorrhagic fever viruses can cause relatively mild illnesses, many of these viruses cause severe life-threatening disease. Some examples include: Lassa fever, Marburg virus, Ebola virus, Bolivian hemorrhagic fever, Korean hemorrhagic fever, Crimean-Congo hemorrhagic fever and Dengue hemorrhagic fever.

No current treatment can cure viral hemorrhagic fevers, and immunizations exist for only two (yellow fever and Argentine hemorrhagic fever) of the many VHFs. Researchers are working to develop other vaccines, but in the meantime, the best approach is prevention.

This volume will provide a review of what is known to date on these virus families as well as highlighting recent advances and future needs.

Tartalomjegyzék:

Paramyxoviruses

Nipah Molecular Biology - Rota, Hadler, Bellini
What are the recent advances in understanding the henipivirus genomes? Modalities to suppress interferon and other innate immune responses? Function of neutralizing antibodies, receptors, etc.

Pathogenesis of Nipah- Sherif Zaki
Human material and to a lesser extent models have helped remarkably to understand how Nipah virus causes disease. What are the major findings, their clinical correlations, and most important unresolved questions.

Epidemiology of Nipah - Chua, Lam
With some time to understand the factors that led to emergence of Nipah in Malaysia, what do we now understand about the timing of its emergence from bats to pigs to humans and the risk factors and spread in the human population? What is known about the control in the different foci in Malaysia? How could it have been recognized and controlled earlier?

New, emergent paramyxoviruses - Mackenzie and Hume Fields
Synthesis of Hendra, Nipah, new Bangladesh agent; plus snake viruses, Mengele, etc. Is this the new fount of emergent viruses? What changes drove these and will drive future emergences? Why is cross species transfer so easy in these newly recognized agents when dogma is that there is a great deal of species specificity?

Bunyaviridae: Phleboviruses and Nairoviruses

Epidemiology of Rift Valley fever, CCHF, and Ngari viruses - Swanpoel
Synthesis of recent molecular with older classical epidemiology to try to understand the distribution, ebb and flow, and human risk from these viruses. Short discussion of Ngari virus.

Pathogenesis and vaccines for Rift Valley fever - C.J. Peters

CCHF: Regional epidemiology

Overview - Doug Watts
Russia and Central Asia- author to be determined
Iran - author to be determined
Turkey - author to be determined
Western China - Saijo, Niikura, Kurane

Molecular biology of CCHF - Clegg

Bunyaviridae: Hantaviruses

Hemorrhagic fever with renal syndrome: Clinical findings, pathogenesis in humans, and viral circulation in the Balkans - Markotic and Tatiana
Interesting observations in all these areas have been made in Croatia and Slovenia (and probably other places in former Yugoslavia) and can be synthesized into a nice review (calling on data from outside the region when illustrative).

Hantavirus pulmonary syndrome: a new animal model and it's lessons for human disease - Jay Hooper and Fred Koster

Flaviruses

Dengue hemorrhagic fever - Farrar
A balanced review to cover the antibody enhancement vs T cell controversy, discuss new understanding of viral factors (viremia, emergence of variants with epidemics of DHF). CNS disease as part of the dengue spectrum (role of myocardial contractility?).

Omsk HF - Netesov and Loktev

Kyasanur Forest disease - author to be determined