Rövid leírás:

Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. The major aim of Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back is to illustrate key advances in the field ? specifically how signals are transmitted to the nucleus in response to neuronal activity, what genes are activated and how this is achieved, and how these changes in gene expression alter neuronal function.

About the Author:

Serena M. Dudek, Ph.D. is best known for her seminal work describing Long-term synaptic Depression (LTD) in the hippocampus. Dr. Dudek heads the Synaptic and Developmental Plasticity Group at the National Institute of Environmental Health Sciences, where her laboratory studies the cellular mechanisms of synaptic plasticity in the adult and developing mammalian brain. Although once a critic of the proposed necessity of transcription for maintenance of synaptic plasticity, Dr. Dudek now devotes much of her time to work on the topic.

Hosszú leírás:

Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. The major aim of Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back is to illustrate key advances in the field ? specifically how signals are transmitted to the nucleus in response to neuronal activity, what genes are activated and how this is achieved, and how these changes in gene expression alter neuronal function.

Tartalomjegyzék:

Activity-regulated Transcription: Getting to the Nucleus.- Transcriptional Regulation of Activity-Dependent Genes by Birdsong.- To the Nucleus with Proteomics.- Transcriptional Regulation of the Tbr1-CASK-CINAP Protein Complex in Response to Neuronal Activity.- Intracellular Calcium Waves Transmit Synaptic Information to the Nucleus in Hippocampal Pyramidal Neurons.- Role of Action Potentials in Regulating Gene Transcription: Relevance to LTP.- L-type Channel Regulation of Gene Expression.- Activity-regulated Transcription: Gene Regulation.- CREB-Dependent Transcription and Synaptic Plasticity.- Activity-Dependent Regulation of Brain-derived neurotrophic factor Transcription.- Role of Signal-responsive Class IIa Histone Deacetylases in Regulating Neuronal Activity-dependent Gene Expression.- NFAT-Dependent Gene Expression in the Nervous System: A Critical Mediator of Neurotrophin-Induced Plasticity.- Activity-Dependent Bigenomic Transcriptional Regulation of Cytochrome c Oxidase in Neurons.- Not Just for Muscle Anymore: Activity and Calcium Regulation of MEF2-Dependent Transcription in Neuronal Survival and Differentiation.- Activity-regulated Transcription: Role in Nervous System Function.- Synaptic Growth and Transcriptional Regulation in Drosophila.- MMP-9/TIMP-1 Extracellular Proteolytic System as AP-1 Target in Response to Neuronal Activity.- Activity-dependent Gene Transcription in Neurons: Defining the Plasticity Transcriptome.- Transcriptional Mechanisms Underlying the Mammalian Circadian Clock.- Intersecting Genetics with Lifestyle: the Role of Exercise and Diet in Synaptic Plasticity and Cognitive Enhancement.- CREB Responsive Transcription and Memory Formation.- Dynamic Transcription of the Immediate-Early Gene Arc in Hippocampal Neuronal Networks: Insights into the Molecular and Cellular Bases of Memory Formation.