The Triptans: Novel Drugs for Migraine
Novel Drugs for Migraine
Sorozatcím: Frontiers in Headache Research series; 10;
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132 575 Ft (126 262 Ft + 5% áfa)
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132 575 Ft
Beszerezhetőség
Megrendelésre a kiadó utánnyomja a könyvet. Rendelhető, de a szokásosnál kicsit lassabban érkezik meg.
Why don't you give exact delivery time?
A beszerzés időigényét az eddigi tapasztalatokra alapozva adjuk meg. Azért becsült, mert a terméket külföldről hozzuk be, így a kiadó kiszolgálásának pillanatnyi gyorsaságától is függ. A megadottnál gyorsabb és lassabb szállítás is elképzelhető, de mindent megteszünk, hogy Ön a lehető leghamarabb jusson hozzá a termékhez.
A termék adatai:
- Kiadó OUP Oxford
- Megjelenés dátuma 2001. november 1.
- ISBN 9780192632142
- Kötéstípus Keménykötés
- Terjedelem358 oldal
- Méret 247x172x24 mm
- Súly 813 g
- Nyelv angol
- Illusztrációk Numerous graphs and line figures 0
Kategóriák
Rövid leírás:
A new era in the treatment of migraine headache arrived with the development of a revolutionary class of drugs known as the triptans. The book reviews the development, pharmacology, mechanisms of action, efficacy and tolerability of the full range of triptans, and will help the clinician to make a logical choice about which triptan to use for which patient.
TöbbHosszú leírás:
A new era in the treatment of migraine headache arrived with development of a revolutionary class of drugs known as the triptans.
The book describes the development of this class of drugs, starting with the discovery of sumatriptin, covers the pharmacology and the mechanisms of action of the full range of triptans, before comparing their clinical efficacy and tolerability. Each drug is described by the company who produces it and then reviewed, based on experimental and clinical evidence, by independent scientists.
This comprehensive review will provide clinicians with guidance on which triptan to select for which patient.
The editors have gathered together the leading international experts to produce a book that will appeal to all neurologists and general physicians caring for headache patients as well as those with research interests in the field.
Tartalomjegyzék:
Section I - Background and early development
The discovery of sumatriptan and a new class of drugs for the acute treatment of migraine
5-HT receptors in brain and vasculature
Structural and operational diversity of Serotonin receptors. Potential relevance to migraine pathophysiology and treatment
Characterisation of 5-HT1 receptor expression in human vasculature
5-HT1B and 5-HT1D receptor immunoreactivity colocalize with sensory neurotransmitters in the human trigeminal ganglion
Upregulation of 5-HT1B/1D receptors during organ culture of cerebral arteries
Background and early development - discussion summary
Section II - Pharmacology of the triptans
Clinical pharmacokinetics of the triptans:what are the important clinical issues?
Pharmacodynamics of triptans
Characteristics of different routes of administration
Encapsulation of sumatriptan does not delay its absorption
Synergism of 5-HT1 and 5-HT2 receptors in sumatriptan-induced vasocontractile response in rabbit common carotid artery
Role of 5-HT1B and 5HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery
Comparison of triptan induced contractions in human cerebral vs coronary arteries
Pharmacological analysis of cotractile effects of eletriptan and sumatriptan on human isolated blood vessels
Pharmacology of the triptans: discussion summary
Section III - Antimigraine actions of the triptans
The importance of vasoconstriction in the mechanism of the antimigraine action of the triptans
Inhibition of neurogenic inflammation is most important
Central nervous system effects are most important
Do we really understand how triptans work?
The relevance of hepatic intrinsic clearance and brain penetration on the doses used for 5-HT agonists (triptans) in the treatment of migraine
In vivo serotonergic effects and extracellular brain levels of centrally and systemically administered eletriptan, zolmitriptan and sumatriptan
Regulation of capsaicin-evoked CGRP release from rat dural sensory neurones in vitro
Arterial distensibility in ergotamine and sumatriptan abuse
Anti migraine actions of the triptans: discussion summary
Section IV - Clinical efficacy and tolerability of the triptans
Sumatriptan: looking back and looking forward
Zolmitriptan offers doctor and patient choices for effective treatment of migraine
Rizatriptan: clinical update
Evidence against tight correlation between chest oppressive symptoms and ischaemic coronary changes after subcutaneous sumatriptan injection
Alteration in cluster headache during subcutaneous administration of sumatriptan
Efficacy and tolerability of rizatriptan 10mg in migraine: experience with 70527 patient episodes
Consistency of pain relief over multiple migraine attacks following treatment with rizatriptan
Naratriptan: the gentle triptan
Experience with eletriptan (RelpaxTM)
Almotriptan
Frovatriptan: simplifying clinical practice in migraine
The cardiovascular safety of frovatriptan in patients at high risk of or with known coronary artery disease during a migraine attack
Lack of clinically significant interactions between frovatriptan and ergotamine, propranolol or moclobemide
Frovatriptan pharmocokinetics are unaffected during a migraine attack
Clinical efficacy and tolerability of the triptans: discussion summary
Section V - The triptans in clinical practice
Acute management of migraine: clinical trials of triptans versus other agents
Which triptans for which patient?
The Framig 99 survey III: therapeutical behaviour of migraineurs
Migraine in France in 2000: therapeutical data
The triptan threshold score: a score tohelp patients identify the best moment to take the triptan
Triptan plus NSAID with long half life: increase of efficacy and reduction of headache recurrence in acute migraine
Comparison of the triptans with other drugs in the development of drug-induced headache
An epidemiological study on the differences between sumatriptan and ergotamine overuse
Overuse of new 5-HT agonists (zolmitriptan and naratriptan) in migraine patients: clinical features
The triptans in clinical practice: discussion summary
