The Implicit Genome by Caporale, Lynn Helena;

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24 832 Ft

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A termék adatai:

Kiadó OUP USA
Megjelenés dátuma 2006. február 23.

ISBN 9780195172713
Kötéstípus Puhakötés
Terjedelem400 oldal
Méret 155x234x20 mm
Súly 576 g
Nyelv angol
Illusztrációk 80 line drawings

Kategóriák

Taxonómia, rendszertan Genetika, evolúció, fejlődéstan Molekuláris biológia Embertan, antropológia Általános mikrobiológia, mikrobák ökológiája

Rövid leírás:

For over half a century, we have been in the thrall of the double-helical structure of DNA, which, in an instant, revealed that information can be transferred between generations by a simple rule, A pairs with T, G pairs with C. In its beautiful simplicity, this structure, along with the table of codons worked out in the following decade, had entranced us into believing that we can fully understand the information content of a DNA sequence, simply by treating it as text that is read in a linear fashion. While we have learned much based on this assumption, there is much we have missed. The chapters in this volume touch on one or more of three interconnected themes: information can be implied, rather than explicit, in a genome; information can lead to focused and/or regulated changes in nucleotide sequences; information that affects the probability of distinct classes of mutation has implications for evolutionary theory.

Több

Hosszú leírás:

Most analyses assume that genomes are to be read as linear text, much as a sequence of nucleotides can be translated into a sequence of amino acids by looking in a table. However, information can evolve in genomes with distinct forms of representation, such as in the structure of DNA or RNA and/or the relationship between nucleotide sequences. Such information has importance to biology yet is largely unexpected and unexplored. As described in this volume, much of this information, through mechanisms ranging from alternative splicing of RNA to the generation of bacterial coat protein diversity, affects the probability of distinct types of alterations in the nucleic acid sequence. Some genomic DNA sequences affect genome stability, handling and organization, with implications for the robustness of lineages over evolutionary time. The examples reviewed in this volume, taken from a broad range of biological organisms, both extend our view of the nature of information encoded within genomes, and can deepen our appreciation of the power of natural selection, through which this information, in its various forms, has emerged.