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  • The Color of Precision Medicine

    The Color of Precision Medicine by Sun, Shirley; Ong, Zoe;

    Sorozatcím: Routledge Studies in Science, Technology and Society;

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    A termék adatai:

    • Kiadás sorszáma 1
    • Kiadó Routledge
    • Megjelenés dátuma 2025. szeptember 29.

    • ISBN 9781032565637
    • Kötéstípus Puhakötés
    • Terjedelem160 oldal
    • Méret 234x156 mm
    • Súly 300 g
    • Nyelv angol
    • Illusztrációk 1 Illustrations, black & white; 1 Line drawings, black & white; 3 Tables, black & white
    • 699

    Kategóriák

    Rövid leírás:

    This book proposes the concept of racialization of precision medicine, defined as the social processes by which racial/ethnic categories are incorporated (or not) into the development, interpretation and implementation of precision medicine research and practice. An important resource on how to deracialize precision medicine

    Több

    Hosszú leírás:

    Will genome-based precision medicine fix the problem of race/ethnicity-based medicine? To answer this question, Sun and Ong propose the concept of racialization of precision medicine, defined as the social processes by which racial/ethnic categories are incorporated (or not) into the development, interpretation, and implementation of precision medicine research and practice.


    Drawing on interview data with physicians and scientists in the field of cancer care, this book addresses the following questions: Who are the racializers in precision medicine, how and why do they do it? Under what conditions do clinicians personalize medical treatments in the context of cancer therapies? The chapters elucidate different ways in which racialization occurs and reveal that there exists an inherent contradiction in the usage of race/ethnicity as precision medicine moves from bench to bedside. The relative resources theory is proposed to explain that whether race/ethnicity-based medicine will be replaced by genomic medicine depends on the resources available at the individual and systemic levels. Furthermore, this book expands on how racialization happens not only in pharmacogenomic drug efficacy studies, but also in drug toxicity studies and cost-effectiveness studies.


    An important resource for clinicians, researchers, public health policymakers, health economists, and journalists on how to deracialize precision medicine.

    Több

    Tartalomjegyzék:

    Table of Contents


     


    1 . Introduction


    Precision medicine (PM): A global phenomenon


    What is precision medicine? Definitions, sites and scale.


    Precision medicine as an alternative to race-based medicine


                What is race-based medicine and racial profiling in medicine?


                Problems with race-based medicine/racial profiling in medicine


                Is genome-based precision medicine really the answer?


       Addressing the debate: Racialization as the key concept


                Racialization of national census categories


                Racialization in science (or, scientific racism) in colonial contexts


    Racialization of medicine in colonial contexts


    Racialization in medicine in contemporary times


    In the (post-)Genomic Era: Racialization of human genomic science


    What is the future of genome-based precision medicine? An empirical examination in cancer care in three post-colonial societies.


    Chapter outline



    2 . Using race to overcome race: An inherent contradiction in precision medicine


    Introduction


    Using race to overcome race: understanding an inherent contradiction in translational precision medicin


                First domain: Searching for the genetic biomarker in scientific                  research


               Second domain: Recruiting suitable human subjects for clinical                 trials


               Third domain: Medical decision-making in the clinic


    Conclusion


     


    3. Trans-National colors: Race, Ethnicity and Genomic Science in the United States of America, Canada and Singapore


    Introduction


    Is race biological or socially constructed? A brief overview.


    Where and how do racialization happen in genomic science?


    Materials for racialization of a population sample and/or patient  


                Issues with the different ways of racialization 


    Perspectives from the genomic science community about the                  relationship between race and genetics


                No clear distinction between ethnoracial population groups


    Genetic heterogeneity within an ethnoracial population group


    Race as a social construct


    If race is socially constructed, why are there differences in frequencies of genetic alleles between racial/ethnic groups?


    If not race, what drives human genomic diversity?


    Conclusion



    4. The “relative resources” model: Heterogeneity of resources and the racialization of precision medicine


    Introduction


    The “personalized medicine” versus “racialized medicine” debate


    “Race is really the poor man’s genomic test”: The relative resources model


    Financial resources


    Human and informatics resources


                Legal and infrastructural resources


    Implications of the relative resources model


    Conclusion


     


    5. Pharmacogenetic/Pharmacogenomic Drug Toxicity Studies, Race/Ethnicity and Managing Adverse Drug Reactions in the Clinic: Ongoing Tensions


    Introduction


    Examples of racialised pharmacogenomic studies in the US, Canada and Singapore


    Allopurinol


    5-Fluorouracil (5-FU)


    Cost-effectiveness studies, race/ethnicity and precision medicine


    Who is Asian and who is Caucasian?


    Debating race/ethnicity-based pharmacogenetic toxicity data in the clinic


    Subjective interpretation of drug toxicity risks


    Toxicity is a multi-factor phenomenon and is not just about                         genetics


    Pharmacogenetics/pharmacogenomics studies and pharmaceutical companies are at odds. 


    Conclusion


     


    6    Conclusion


    What is already known on the topics of race-based medicine, precision medicine, and the molecularization of race?


    What does this book add to the existing state of the art?


    What are the arguments and findings in each chapter?


    How might this study affect research, practice or policy? 


                Research


    Practice


    Policy


    Science communication by scientists and journalists


    Medical education


    What should different stakeholders take away from this book?


    Scientists


    Physicians/medical doctors


    Public policy makers


    Health economists


     What are the theoretical and empirical contributions of this book?


    On “racialization”


    On the nexus of relative resources and racialization of precision              medicine


    On differential racialization


    What are the tensions with the usage of race/ethnicity in genomic science with medical and public health implications?


        What are some of the limitations of this study?


        What are some of the future research projects based on this book?

    Több