Targeted Radiopharmaceuticals and Imaging by Srivastava, Ved; Vatsa, Rakhee; Ved Srivastava;

Rövid leírás:

Bringing a cohesive picture on different radiopharmaceutical therapies for cancer treatment, this book will address the challenges in developing and commercialising radiopharmaceuticals.

Hosszú leírás:

Targeted radiopharmaceutical therapy (RPT) is emerging as an innovative approach for treating a wide range of cancers.

Almost all radionuclides used in RPT emit photons that can be imaged, enabling non-invasive visualization of the therapeutic agent's biodistribution. The remarkable potential of radiopharmaceutical therapy is now being recognized with recent FDA approval of several RPT drugs and a significant number of drug candidates in clinical development.

This book offers a comprehensive perspective on the different technologies and addresses the critical challenges in developing and commercializing radiopharmaceuticals. It covers various topics, from clinical applications to specific radiopharmaceutical biodistribution, dosimetry, and novel targets in oncology. The chapters provide a cohesive picture of the advances in SPECT/CT and PET/CT imaging, clinical trends in targeted therapies utilizing radioisotopes for cancer imaging, and clinical applications of radiotracers within oncology areas. It also delves into the manufacturing technologies and regulatory and supply logistics required to support the development of the next wave of targeted alpha therapies.

This resource is ideal for postgraduates and researchers in drug discovery and development in radionuclide therapy and imaging in cancer, as well as medical professionals engaged in nuclear medicine and radiology.

Tartalomjegyzék:

Targeted Radiopharmaceuticals: Clinical Development and Commercial Landscape
Advances in Targeted Radiopharmaceuticals: Challenges and Opportunities
Alpha-particle Emitting Radiopharmaceuticals in Targeted Therapy and Diagnostics: Challenges and Opportunities
Chelator Design and Radiolabeling Chemistry of Radiometals
Dosimetry Methods for Radiopharmaceuticals
Glypican-3 (GPC3) Targeted Radiopharmaceuticals for Treatment of Liver Cancer
Identifying New Molecular Modalities for Radionuclide Therapy Using Macrocyclic Peptide Mimetics
Peptides and Small Radiopharmaceuticals for Molecular Targeting
Antibody Based Radiopharmaceuticals in Clinical Development
Prostate-specific Membrane Antigen Targeted Prostate Imaging and Therapy
Radiotracers for Imaging of Breast Cancer and Targeted Radionuclide Therapy
Neuroendocrine Tumors: Radiopharmaceuticals for Imaging and Therapy
Radiopharmaceuticals for Imaging and Therapy in Neurology
Thyroid Imaging and Radionuclide Therapy
Radiopharmaceuticals for Skeletal Imaging and Therapy
Radiopharmaceuticals in Dermatologic Imaging and Therapy
Targeted Radiopharmaceuticals for Infection Imaging
Manufacturing Challenges and Radiopharmaceutical Application of ¹⁸F-labeled Heterocycles for PET Imaging
Quality Considerations in Radiopharmaceuticals