Parkinson Disease
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65 690 Ft (62 562 Ft + 5% áfa)
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65 690 Ft
Beszerezhetőség
Becsült beszerzési idő: A Prosperónál jelenleg nincsen raktáron, de a kiadónál igen. Beszerzés kb. 3-5 hét..
A Prosperónál jelenleg nincsen raktáron.
Why don't you give exact delivery time?
A beszerzés időigényét az eddigi tapasztalatokra alapozva adjuk meg. Azért becsült, mert a terméket külföldről hozzuk be, így a kiadó kiszolgálásának pillanatnyi gyorsaságától is függ. A megadottnál gyorsabb és lassabb szállítás is elképzelhető, de mindent megteszünk, hogy Ön a lehető leghamarabb jusson hozzá a termékhez.
A termék adatai:
- Kiadó OUP USA
- Megjelenés dátuma 2022. október 13.
- ISBN 9780190843014
- Kötéstípus Keménykötés
- Terjedelem304 oldal
- Méret 184x259x24 mm
- Súly 862 g
- Nyelv angol 253
Kategóriák
Rövid leírás:
Parkinson Disease is a comprehensive introduction to the biology and clinical features of Parkinson disease (PD). Topics covered include nosology of PD, PD epidemiology, pathology and pathophysiology of PD, and theories of PD pathogenesis. This book intends to be a useful overview, bridging the gap between general textbooks and specific topical reviews.
TöbbHosszú leírás:
Parkinson Disease is a comprehensive introduction to the biology and clinical features of Parkinson disease (PD). This book is aimed at clinicians in training, general neurologists seeking a useful guide to PD, and scientists seeking an overview of clinical aspects of PD. Topics covered include nosology of PD, PD epidemiology, pathology and pathophysiology of PD, and theories of PD pathogenesis. Clinical features, including the many non-motor features, natural history of disease progression, clinical pharmacology, and management of PD receive coverage. Important themes are heterogeneity of PD, the multi-focal nature of PD pathology, the diversity of clinical features, dopaminergic signaling and the impacts of dopaminergic deficiency, the importance of non-motor features, limitations of existing treatment modalities, and the necessity of approaching PD as a multi-system disorder. The description and discussion of the many aspects of Parkinson disease (PD) is dogged by the fact that PD is an ambiguous concept. This book intends to be a useful overview, bridging the gap between general textbooks and specific topical reviews.
TöbbTartalomjegyzék:
Chapter 1: Definition, History, Nosology, and Classification
Introduction and Definition
Brief History of PD
Nosology and Classification Scheme
Classification Level 1
Classification Level 2
Ambiguities and Future Directions
Conclusion
Chapter 2: Epidemiology
Introduction
Prevalence
Incidence
Mortality
Risk Factors
Implications for Understanding Etiopathogenesis and the Future Burden of PD
Chapter 3: Pathology
Introduction
The Aging Brain
Gross Pathology, Lewy Pathology, and a-Synucleinopathy
Substantia Nigra Pars Compacta Pathology
Idiopathic Lewy Body Disease (iLBD)
The Braak et al. Staging System
Synucleinopathy Outside the Brain
Non-Synuclein Pathologies
Chapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard Model
Introduction
Basic Basal Ganglia Architecture
The "Standard" Model of Basal Ganglia Pathophysiology
Complexities of Basal Ganglia Architecture
Conclusion
Chapter 5: Pathophysiology II - Neurotransmitter System Dysfunctions
Introduction
Nigrostriatal Dopamine Signaling Functions
Habit Formation and Chunking
Cholinergic Projection System Dysfunctions
Serotoninergic System Dysfunctions
Conclusions and Future Challenges
Chapter 6: Genetics of Parkinson Disease
Introduction
Dominant Forms of PD
Recessive Forms of PD
GBA
PD Genetic Risk Factors
Implications of PD Genetic Research
Chapter 7: Pathogenesis
Neuronal Vulnerability
Alpha-Synuclein
The Prion-Like Hypothesis
Mitochondrial Dysfunction
Oxidative Stress
Endolysosomal Dysfunction
Neuroinflammation
Neuroprotection Trials
Conclusions
Chapter 8: Prodromal Parkinson Disease
Introduction
REM Sleep Behavior Disorder
Observational Studies
REM Sleep Behavior Disorder Cohort Studies
Genetic Cohort Studies
Autonomic Failure
Future Directions
Chapter 9: Clinical Features I - Initial Evaluation
Presentation Features
Nature of Diagnosis and Diagnostic Criteria
History and Examination
Differential Diagnosis
Treatment Responsiveness
Diagnostic Accuracy
Chapter 10: Clinical Features II - Non-Motor Features
Introduction
Cognitive Impairments
Neuropsychiatric Disorders
Sleep Disorders
Pain
Fatigue
Autonomic Disorders
Visual Disorders
Oral Health
Conclusion
Chapter 11: Clinical Features III - Natural History
Introduction
Assessing PD Progression
PD Progression - Clinically Salient Features
Subgroups
Natural History Summary
Continuing Care
End of Life Care
Chapter 12: Pharmacology I - L-Dopa Pharmacokinetics and Pharmacodynamics
Introduction
Dopaminergic Neurotransmission
L-Dopa Pharmacokinetics
L-Dopa Pharmacodynamics
Peak Dose Dyskinesias
Interactions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future Directions
Chapter 13: Pharmacology II - Treating Parkinson Disease
Introduction
Using L-Dopa
When the Honeymoon Is Over
L-Dopa Adjuncts
Dopamine Agonists
Cholinergic Agents
Other Symptomatic Therapies
Future Directions
Chapter 14: Surgery
Introduction
Deep Brain Stimulation: Rationale and Possible Mechanisms
Deep Brain Stimulation: Procedures
Deep Brain Stimulation: STN DBS Benefits
Deep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBS
Deep Brain Stimulation: Adverse Events
Lesional Procedures
Cell-Based and Gene Therapies
Future Directions
Coda: Looking Ahead
