Nonmalignant Hematology by Abutalib, Syed A.; Connors, Jean M.; Ragni, Margaret V.;

Hosszú leírás:

This book, in Q&A format, addresses a wide range of clinically relevant topics and issues in Nonmalignant Hematology, or “Benign Hematology,” with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. The entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. The content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related disorders, hemostasis and thrombosis during pregnancy and in the newborn and elderly, and Transfusion Medicine. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in Nonmalignant Hematology. Readers willfind that it provides a practical and immediately applicable compendium of answers to often complex and vexing questions. It will appeal to residents, fellows, house officers and more experienced practitioners around the globe.

Tartalomjegyzék:

"

Part 1. Red Blood Cells.- Evaluation of anemia in children and adults.- Iron cycle and pathophysiology of iron homeostasis.- Porphyrias: Diagnosis and management.- Disorders of hemoglobin synthesis: Pathophysiology and diagnostic evaluation.- Management of thalassemias.- Allogeneic hematopoietic cell transplant in ß-thalassemia major.- Sickle cell disease: Prevention of complications.- Sickle cell disease: Management of complications.- Allogeneic hematopoietic cell transplant in sickle cell disease.- Anemia of inflammation.- Iron overload: Diagnosis, complications and management.- Megaloblastic and nutritional anemias.- Sideroblastic anemias: Diagnosis and management.- Primary autoimmune warm antibody hemolytic anemias.- Intrinsic hemolytic anemias: Pathophysiology, diagnosis and management.- Part 2. Platelets and Coagulation System.- Platelet disorders: Diagnostic tests and their interpretations.- Inherited platelet disorders: Diagnosis and management.- Acquired platelet disorders: Diagnosis and management.- Immune mediated thrombocytopenia.- Coagulation cascade and fibrinolysis pathway: Assessment in the laboratory.- Abnormalities in fibrinolysis pathway and clinical implications.- Congenital disorders of fibrinogen: Clinical presentations, diagnosis and management.- Hemophilias A and B: Diagnosis and management.- Coagulation factor inhibitors: Diagnosis and management.- Rare coagulation factor deficiencies: Diagnosis and management.- von Willebrand disease: Differential diagnosis and diagnostic approach to specific subtypes.- von Willebrand disease: Prevention of complications and management of the disease.- Antifibrolytics: Indications and precautions.- Gene therapy for bleeding disorders.- Part 3. Coagulopathy in Systemic Diseases.- Disseminated intravascular coagulopathy.- Coagulopathy in critically ill subjects.- Trauma-associated coagulopathy.- Coagulation related issues in malignant hematology: Diagnosis and management.- Unmet clinicalneeds of antithrombotic treatment in BCR/ABL negative myeloproliferative neoplasms.- Bleeding and thrombosis in a cancer patient.- Management of surgical patient with thrombotic and bleeding diathesis.- Part 3. Thrombosis and Therapeutics.- Prevention and treatment of arterial thromboembolism.- mes New Roman"",""serif"""">Prevention of venous thromboembolism.- Diagnostic, prognostic and therapeutic challenges in venous thromboembolisim.- Complications of venous thromboembolic disease.- Hereditary thrombophilias: Pathophysiology, timing of testing and familiar testing.- Anti-phospholipid antibodies and syndrome: Complexities in diagnosis and management.- Unidentifiable thrombophilias.- Anticoagulation drugs: Indications, therapeutic monitoring and antidotes.- Heparin induced thrombocytopenia: Diagnosis and management.- Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.- Surgical treatment of thromboembolic disease.- Part 4. Immune System and Related Disorders.- Nonmalignant leukocyte disorders.- Primary immunodeficiency disorders: Diagnosis and management.- Disorders of phagocytic function: Diagnosis and treatment.- Inherited bone marrow failure syndromes.- Hemophagocytic lymphohistiocytosis: Diagnosis and management challenges.- Lysosomal storage disorders: Hematology perspective.- Cryoglobulins and cryoglobulinemia.- Part 5. Hemostasis and Thrombosis in Pregnancy, Newborn and Elderly.- Reproductive issues in women with bleeding and thrombotic disorders.- Pregnancy in subjects with hemoglobinopathies: Precautions and management.- Neonatal thrombosis and coagulopathies.- Bleeding and thrombosis in elderly.- Part 6. Transfusion Medicine.- Transfusion support: Indications, efficacy and complications.- Human blood antigens and antibodies: Diagnostic and therapeutic implications.- Therapeutic apheresis in hematologic disorders: When and Why?