Microglial Aging by Tremblay, Marie-Eve;

Basic, Translational and Clinical Advances

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A termék adatai:

Kiadó Academic Press
Megjelenés dátuma 2026. február 13.

ISBN 9780443273407
Kötéstípus Puhakötés
Terjedelem350 oldal
Méret 235x191 mm
Súly 450 g
Nyelv angol

Kategóriák

Geriátria és gerontológia

Hosszú leírás:

Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.

This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.

Covers basic, translational, and clinical research advances in microglial aging
Reviews the most up-to-date research findings on microglial aging and their implication in age-related neurodegenerative diseases
Includes current knowledge on the effects of lifestyle on microglial aging and on promising strategies, both pharmacological and non-pharmacological, for rejuvenating microglia

Több

Tartalomjegyzék:

Section 1. Introduction to microglial aging and its involvement in neurodegenerative diseases
1. The microglial aging process at cellular and molecular levels across its different layers of complexity
2. Involvement of microglial aging in neurodegenerative diseases: a focus on Alzheimer’s disease
3. Involvement of microglial aging in neurodegenerative diseases: a focus on Parkinson’s disease
4. Involvement of microglial aging in neurodegenerative diseases: a focus on multiple sclerosis
5. Involvement of microglial aging in neurodegenerative diseases: a focus on amyotrophic lateral sclerosis
6. Involvement of microglial aging in neurodegenerative diseases: a focus on vascular cognitive impairment and dementia

Section 2. Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory
7. Diet and the gut-brain axis
8. Sleep disturbances
9. Psychological stress
10. Bacterial and viral infections
11. Physical activity
12. Substance use

Section 3. Emerging treatment strategies to rejuvenate microglia in aging and neurodegenerative diseases
13. Ketogenic diets and supplements
14. Senolytic drugs
15. Cannabinoids
16. Psychedelics
17. Plasmalogens
18. Multi-modal lifestyle interventions