Ethical Issues in International Biomedical Research
A Casebook
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A termék adatai:
- Kiadó OUP USA
- Megjelenés dátuma 2007. március 22.
- ISBN 9780195179224
- Kötéstípus Keménykötés
- Terjedelem400 oldal
- Méret 163x236x25 mm
- Súly 686 g
- Nyelv angol 0
Kategóriák
Rövid leírás:
The ethics of biomedical research in developing countries is hotly debated. Utilising 21 cases of actual research trials, this book explores a wide range of ethical challenges in conducting research in developing countries. Commentaries are provided by leading scholars on international research ethics as well as by many new voices, including authors from developing countries.
TöbbHosszú leírás:
Ethical Issues in International Biomedical Research is the definitive book on the ethics of research involving human subjects in developing countries. Using 21 actual case studies, it covers the most controversial topics, including the ethics of placebo research in Africa, what benefits should be provided to the community after completion of a research trial, how to address conflicts between IRBs in developed and developing countries, and undue inducement of poor people in developing countries. Each case is accompanied by two expert commentaries, written by many of the worlds leading experts in bioethics as well as new voices with research experience in developing countries. No other volume has this scope.
This is a well-written book and a must-read for anyone trying to understand the concerns associated with international biomedical research. The cases address research in many parts of the world on different disorders and conditions. The commentaries give readers a better appreciation of the breadth and depth of the relevant ethical issues.
Tartalomjegyzék:
FOREWORD
INTRODUCTION
SECTION I: COLLABORATIVE PARTNERSHIP
Case 1. Community involvement in biodiversity prospecting in Mexico
Case 2. Selling genes: consulting a genetic population database in Tonga
Case 3: Substantiality of a fluoride varnish feasability study in Nicaragua
SECTION II: SCIENTIFIC VALIDITY
Case 4: Malarone testing in pregnant women in Thailand
Case 5: Neglected diseases: Incentives to Conduct Research in Developing Countries: the case of Pharamomycin for visceral leishmaniasis in India
SECTION III: SCIENTIFIC VALIDITY
Case 7. The limitations of knowledge: equipsoise and a randomized treatment strategy for malaria in Ethiopia
Case 8. Controversy surrounding the scientific value of the Vaxgen/Aventis (RV-144) Phase III
SECTION IV: FAIR SUBJECT AND COMMUNITY SELECTION
Case 9. Pharmaceutical research in developing countries: testing a new sufracant in Bolivia
Case 10: Trading Genes for Toothbrushes: Research with the Aka Pygmy people in the Central African Republic
Case 11: Test Phase I malaria vaccine: where should the research be conducted?
SECTION V: FAVOURABLE RISK/BENEFIT ASSESSMENT
Case 12: Ethical complcations during an investigation of malaria infection in native Amazonian populations in western Brazil
Case 13: Access to treatment for trial participants who become infected with HIV during the course of Phase I trials of a preventive HIV vaccine in South Africa
SECTION VI: INDEPENDENT REVIEW
Case 14: How independent is independent review? Partner notification in a study of sexually-transmitted diseases in Mpumalanga, South Africa
Case 15: Which regulations protect subjects best: preventing HIV status disclosure in a community-based circumcision study in rural Uganda
SECTION VII: INFORMED CONSENT
Case 16: The challenge of informed consent in a genetic epidemiology study of noma in rural Nigeria
Case 17: Compensation to families who consent to research autopsy for their children in a study of malaria mortality in Malawi: respectful or coercive?
SECTION VIII: RESPECT FOR ENROLLED SUBJECTS AND THEIR COMMUNITIES
Case 18: A randomized trial of low-phytate corn for maternal-infant micronutrient deficiency in Guatemala
Case 19: Obligations to participants harmed in the course of the N-9 multi-centre vaginal microbicide trial in South Africa
Case 20: Ethical challenges and controversy in a retrospective study of HIV-1 transmission in Uganda
Case 21: Protecting subjects in a study of domestic violence in South Africa: what services are researchers obligated to provide?
APPENDIX I: ECONOMIC, SOCIAL, HEALTH AND DEVELOPMENT INDICATORS FOR THE CASE COUNTRIES
