Tissue Engineering by Fisher, John P.; Mikos, Antonios G.; Bronzino, Joseph D.;

Short description:

The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Bringing in a diverse group of international contributors with backgrounds in academia, clinical medicine, and industry, this volume surveys advances in this relatively young area. Divided into three sections, it discusses the fundamental concepts of tissue engineering, enabling technologies, and tissue engineering applications. It examines strategies that incorporate scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques that are being applied in regenerative medicine.

Long description:

Increasingly viewed as the future of medicine, the field of tissue engineering is still in its infancy. As evidenced in both the scientific and popular press, there exists considerable excitement surrounding the strategy of regenerative medicine. To achieve its highest potential, a series of technological advances must be made. Putting the numerous breakthroughs made in this field into a broad context, Tissue Engineering disseminates current thinking on the development of engineered tissues.

Divided into three sections, the book covers the fundamentals of tissue engineering, enabling technologies, and tissue engineering applications. It examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue engineered devices. Contributions focus on those strategies typically incorporated into tissue engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques. Finally, the book presents synthetic tissues and organs that are currently under development for regenerative medicine applications.

The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the handbook, Tissue Engineering surveys the latest advances in this relatively young area. The contributing authors are a diverse group with backgrounds in academia, clinical medicine, and industry. Furthermore, the text includes contributions from Europe, Asia, and North America, helping to broaden the views on the development and application of tissue engineered devices.

Table of Contents:

Fundamentals of Tissue Engineering. Fundamentals of Stem Cell Tissue Engineering. Growth Factors and Morphogens: Signals for Tissue Engineering. Extracellular Matrix: Structure, Function, and Applications to Tissue Engineering. Mechanical Forces on Cells. Cell Adhesion. Cell Migration. Inflammatory and Immune Responses to Tissue Engineered Devices. Enabling Technologies. Polymeric Scaffolds for Tissue Engineering Applications. Calcium Phosphate Ceramics for Bone Tissue Engineering. Biomimetic Materials. Nanocomposite Scaffolds for Tissue Engineering. Roles of Thermodynamic State and Molecular Mobility in Biopreservation. Drug Delivery. Gene Therapy. Tissue Engineering Bioreactors. Animal Models for Evaluation of Tissue-Engineered Orthopedic Implants. The Regulation of Engineered Tissues: Emerging Approaches. Tissue Engineering Applications. Bioengineering of Human Skin Substitutes. Nerve Regeneration: Tissue Engineering Strategies. Gene Therapy and Tissue Engineering Based on Muscle-Derived Stem Cells: Potential for Musculoskeletal Tissue Regeneration and Repair. Tissue Engineering Applications —Bone. Cartilage Tissue Engineering. Tissue Engineering of the Temporomandibular Joint. Engineering Smooth Muscle. Esophagus: A Tissue Engineering Challenge. Tissue Engineered Vascular Grafts. Cardiac Tissue Engineering: Matching Native Architecture and Function to Develop Safe and Efficient Therapy. Tissue Engineering of Heart Valves. Tissue Engineering, Stem Cells and Cloning for the Regeneration of Urologic Organs. Hepatic Tissue Engineering for Adjunct and Temporary Liver Support. Tissue Engineering of Renal Replacement Therapy. The Bioengineering of Dental Tissues. Tracheal Tissue Engineering.